anti-FLT3 (FLT3) 抗体产品概述

Full name:
anti-Fms-Related tyrosine Kinase 3 抗体 (FLT3)
在www.antibodies-online.cn可供366 Fms-Related tyrosine Kinase 3 (FLT3) 抗体的33不同的供货商。 再加上,我们可以发FLT3 试剂盒 (40)FLT3 蛋白 (28)和数多这个蛋白质的别的产品。 总共445 FLT3产品已列进来了。
别名:
B230315G04, CD135, FLK-2, FLK2, Flt-3, FLT3, Ly72, STK1, wmfl

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引用最多的anti-FLT3 抗体

  1. Human Polyclonal FLT3 Primary Antibody for EIA, IHC (p) - ABIN359869 : Seidlits, Reza, Briand, Sereno: Voluntary spatial attention has different effects on voluntary and reflexive saccades. in TheScientificWorldJournal 2003 (PubMed)
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  2. Human Monoclonal FLT3 Primary Antibody for FACS, IP - ABIN614773 : Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. in Blood 1997 (PubMed)
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  3. Human Polyclonal FLT3 Primary Antibody for FACS, IHC (p) - ABIN391981 : Minami, Yamamoto, Kiyoi, Ueda, Saito, Naoe: Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. in Blood 2003 (PubMed)
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  4. Human Polyclonal FLT3 Primary Antibody for IHC (p), WB - ABIN391982 : Zwaan, Meshinchi, Radich, Veerman, Huismans, Munske, Podleschny, Hählen, Pieters, Zimmermann, Reinhardt, Harbott, Creutzig, Kaspers, Griesinger: FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. in Blood 2003 (PubMed)
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  5. Human Polyclonal FLT3 Primary Antibody for IF, WB - ABIN401556 : Sekine, Kataoka, Fukuyama, Adachi, Davydova, Yamamoto, Kobayashi, Fujihashi, Suzuki, Curiel, Shizukuishi, McGhee, Fujihashi: A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
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  6. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1532338 : Rosnet, Schiff, Pébusque, Marchetto, Tonnelle, Toiron, Birg, Birnbaum: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. in Blood 1993 (PubMed)
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  7. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1532044 : Rosnet, Matteï, Marchetto, Birnbaum: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene. in Genomics 1991 (PubMed)
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  8. Human Polyclonal FLT3 Primary Antibody for ELISA, WB - ABIN1531319 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
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更多抗FLT3的相互作用对抗体

Mouse (Murine) Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. the angiogenic factor (显示 VEGFA 抗体) Egfl7 (显示 EGFL7 抗体) activates the Flt3/Flt3 ligand (显示 FLT3LG 抗体) pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity

  2. the Hoxa9 (显示 HOXA9 抗体)- and Meis1 (显示 MEIS1 抗体)-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML (显示 RUNX1 抗体) pathology.

  3. lineage-specific STAT5 (显示 STAT5A 抗体) activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype in mice

  4. DOCK2 (显示 DOCK2 抗体) is a potential therapeutic target for novel AML (显示 RUNX1 抗体) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  5. Used a genetic model to determine whether miR (显示 MLXIP 抗体)-155 influences the development of FLT3-ITD-induced myeloproliferative disease. miR (显示 MLXIP 抗体)-155 promotes FLT3-ITD-induced myeloid expansion in the bone marrow, spleen, and peripheral blood. Mechanistically, miR (显示 MLXIP 抗体)-155 increases proliferation of the hematopoietic stem and progenitor cell compartments by reducing the growth-inhibitory effects of the interferon (显示 IFNA 抗体) response.

  6. Overexpression of Abl (显示 ABL1 抗体)-related gene tyrosine kinase (显示 TYRO3 抗体) ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.

  7. Sorafenib-resistant leukemia cells with a FLT3/ITD mutation are sensitive to glycolytic inhibitors.

  8. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21 (显示 D4S234E 抗体)/Pbx1 (显示 PBX1 抗体) axis

  9. Data indicate that most Fms-like tyrosine kinase-3 (FLT3) tyrosine kinase (显示 TYRO3 抗体) inhibitors (TKI) effectively target wild-type FLT3 signaling.

  10. DNMT3A (显示 DNMT3A 抗体) haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML (显示 RUNX1 抗体).

Human Fms-Related tyrosine Kinase 3 (FLT3) interaction partners

  1. FLT3 mutation is associated with Metaplastic Breast Cancer.

  2. Collectively, we have developed a novel targeted therapeutic strategy, using FLT3L (显示 FLT3LG 抗体)-guided miR (显示 MLXIP 抗体)-150-based nanoparticles, to treat FLT3-overexpressing AML (显示 RUNX1 抗体) with high efficacy and minimal side effects.

  3. Y842 is critical for FLT3-mediated RAS/ERK (显示 EPHB2 抗体) signaling and cellular transformation.

  4. value of FLT3-ITD allelic ratio in AML (显示 RUNX1 抗体) in risk assessment and evaluating prognosis

  5. DOCK2 (显示 DOCK2 抗体) is a potential therapeutic target for novel AML (显示 RUNX1 抗体) treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents.

  6. Gedatolisib significantly extended survival of mice in a sorafenib-resistant acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)) patient-derived xenograft model. Taken together, our data suggest that aberrant activation of the PI3K (显示 PIK3CA 抗体)/mTOR (显示 FRAP1 抗体) pathway in FLT3-ITD-dependent AML (显示 RUNX1 抗体) results in resistance to drugs targeting FLT3.

  7. HHEX (显示 HHEX 抗体) could replace RUNX1 (显示 RUNX1 抗体) in cooperating with FLT3-ITD to induce Acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)).

  8. mutated FLT3-ITD and JAK2 (显示 JAK2 抗体) augment reactive oxygen species production and homologous recombination, shifting the cellular milieu toward illegitimate recombination.

  9. these data reveal a novel mechanism which regulates acute myeloid leukemia (显示 BCL11A 抗体) cell death by ceramide-dependent mitophagy in response to FLT3-ITD targeting.

  10. MSI2 (显示 MSI2 抗体) and FLT3 are significantly co-regulated in human AML (显示 RUNX1 抗体)

FLT3 抗原简介

Antigen Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative names and synonyms associated with FLT3

  • fms-related tyrosine kinase 3 (FLT3) 抗体
  • FMS-like tyrosine kinase 3 (Flt3) 抗体
  • fms-related tyrosine kinase 3 (Flt3) 抗体
  • B230315G04 抗体
  • CD135 抗体
  • FLK-2 抗体
  • FLK2 抗体
  • Flt-3 抗体
  • FLT3 抗体
  • Ly72 抗体
  • STK1 抗体
  • wmfl 抗体

Protein level used designations for FLT3

fms-related tyrosine kinase 3 , FL cytokine receptor-like , FL cytokine receptor , fetal liver kinase 2 , receptor-type tyrosine-protein kinase FLT3 , tyrosine-protein kinase FLT3 , tyrosine-protein kinase receptor flk-2 , CD135 antigen , STK-1 , fms-like tyrosine kinase 3 , growth factor receptor tyrosine kinase type III , stem cell tyrosine kinase 1 , FMS-like tyrosine kinase 3

GENE ID SPECIES
452508 Pan troglodytes
100061780 Equus caballus
100413316 Callithrix jacchus
14255 Mus musculus
2322 Homo sapiens
140635 Rattus norvegicus
486025 Canis lupus familiaris
512700 Bos taurus
100858422 Gallus gallus
100515445 Sus scrofa
100732047 Cavia porcellus
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