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EPHB4 is a critical regulator of early lymphatic vascular development; mutations in the gene can cause an autosomal dominant form of LRHF that is associated with a high mortality rate
These results identify EPHB4/ephrin B2 (显示 EFNB2 ELISA试剂盒) signaling as critical to Hematopoietic stem and progenitor cells mobilization from bone marrow
EphB4 plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 (显示 EFNB2 ELISA试剂盒) can be effectively compensated, most possibly by other ephrins with similar chemical structures
Eph (显示 EPHA1 ELISA试剂盒)-B4 stimulates eNOS (显示 NOS3 ELISA试剂盒) phosphorylation in vitro and may mediate vein graft adaptation by regulation of eNOS (显示 NOS3 ELISA试剂盒) activity in vivo.
These data indicate that ephrinB2 (显示 EFNB2 ELISA试剂盒)/EphB4 signaling within the osteoblast lineage is required for late stages of osteoblast differentiation.
EphB4 promotes endochondral ossification while inhibiting osteoclast development during callus formation.
Selective inhibition of EphB4 using a functional blocking antibody results in defective lymphatic valve development.
Overexpression of bone-specific Ephb4 clearly demonstrated prevention of the development and/or progression of fibrosis in OA synovial membrane
EphB4-forward signaling plays a crucial role in the development of cardiac progenitor cells.
EPHB4 plays an essential role in regulating small artery contractility and blood pressure
Inhibition of EphB4 forward signaling using soluble EphB4 protein fused (显示 AXIN1 ELISA试剂盒) with murine serum albumin (显示 ALB ELISA试剂盒) failed to affect eRMS model tumor progression, but did moderately slow progression in murine aRMS
EPHB4 mutations were identified in patients with multifocal capillary malformation with arteriovenous malformations.
EPHB4 is a critical regulator of early lymphatic vascular development; mutations in the gene can cause an autosomal dominant form of lymphatic-related hydrops fetalis that is associated with a high mortality rate
The expression of EPHB4 was increased in gastric cancer and increased EPHB4 expression was correlated with poor survival. Knockdown of EPHB4 promoted adhesion and exerted diverse effects on migration of gastric cancer cells.
EphB4 protein acts as a tumour promoter associated with proliferation, invasion, and angiogenesis, and may be used as a potential colorectal cancer (CRC (显示 CALR ELISA试剂盒)) therapeutic target.
Study illustrates that aberrant activation of EphB4/ephrinB2 (显示 EFNB2 ELISA试剂盒) may mediate chronic myeloid leukemia (显示 BCL11A ELISA试剂盒) resistance involved in cytoskeletal proteins.
both EphA2 (显示 EPHA2 ELISA试剂盒) and EphB4 show potential as target for image-guided colorectal cancer surgery, but EphB4 seems to have the best characteristics with respect to tumor/normal mucosa distribution.
Survival analysis showed that the non-small cell lung carcinoma patients with enhanced expression of CK7 (显示 KRT7 ELISA试剂盒), ELF3 (显示 ELF3 ELISA试剂盒), EGFR (显示 EGFR ELISA试剂盒), and EphB4 mRNA in peripheral blood leukocytes had poorer disease-free survival and overall survival than those without.
Enhanced EphB4 expression was significantly associated with Thyroid Lesions.
LISA method may be considered rapid and sensitive enough to detect even low levels of total and phosphorylated EphB4 Cost-effectiveness of this method for the detection of differential expression of EphB4 proteins in clinics is also noticeable.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
EPH receptor B4
, eph receptor tyrosine kinase
, ephrin receptor EphB4
, ephrin type-B receptor 4-like
, developmental kinase 2
, ephrin type-B receptor 4
, hepatoma transmembrane kinase
, tyrosine kinase MYK-1
, soluble EPHB4 variant 1
, soluble EPHB4 variant 2
, soluble EPHB4 variant 3
, tyrosine-protein kinase TYRO11
, tyrosine-protein kinase receptor HTK