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Human Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN624940
Vizio, Biasi, Scirelli, Novarino, Prati, Ciuffreda, Montrucchio, Poli, Bellone: Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors. in Journal of translational medicine 2013
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Human Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN414354
Li, Liu, Bin, Wang, Chen, Xiu, Pei, Lai, Chen, Fan, Xie, Tao, Wu: Mutant hypoxia inducible factor-1? improves angiogenesis and tissue perfusion in ischemic rabbit skeletal muscle. in Microvascular research 2011
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Mouse (Murine) Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN2683446
Bi, Niu, Ding, Zhang, Yang, Gu: Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism. in Molecular and cellular endocrinology 2016
Shear stress activated Ang-2 via canonical Wnt (显示 WNT2 ELISA试剂盒) signaling in vascular endothelial cells, and Wnt (显示 WNT2 ELISA试剂盒)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (显示 TEK ELISA试剂盒) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (显示 TEK ELISA试剂盒) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (显示 TEK ELISA试剂盒) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (显示 TIE1 ELISA试剂盒) in inflammation leads to ANG2 antagonism of Tie2 (显示 TEK ELISA试剂盒) and initiates a positive feedback loop wherein FOXO1 (显示 FOXO1 ELISA试剂盒)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (显示 ANGPT1 ELISA试剂盒)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (显示 NME1 ELISA试剂盒) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (显示 MLXIP ELISA试剂盒)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (显示 ANGPT1 ELISA试剂盒) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (显示 IL18 ELISA试剂盒) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
We demonstrate that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (显示 TEK ELISA试剂盒) receptor and partly directly via tumor cell surface integrin &1.
ANG2 did not affect apoptosis or the cell cycle. In contrast, in the in vivo system, overexpression of ANG2 increased tumor growth.
When Tie2 (显示 TEK ELISA试剂盒) becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2 (显示 TEK ELISA试剂盒), Angiopoietin-1 (显示 ANGPT1 ELISA试剂盒) and Angiopoietin-2, regulate its activation status.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (显示 IL6 ELISA试剂盒) (40.2pg/mL), VEGF-A (显示 VEGFA ELISA试剂盒) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (显示 PRAP1 ELISA试剂盒) (248.1pg/mL), sHER-2/neu (显示 ERBB2 ELISA试剂盒) (5010pg/mL) and PLGF (显示 PGF ELISA试剂盒) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Gab1/SHP2 (显示 PTPN11 ELISA试剂盒)/p38MAPK (显示 MAPK14 ELISA试剂盒) signaling pathway and Ang-2 have an essential role in regulating thrombin (显示 F2 ELISA试剂盒)-induced monocyte adhesion and vascular leakage
This study demonstrated that ANGPT2 higher expression in glioblastoma.
These observations provide the first evidence for positive regulation of osteogenesis by ANGPT2 in vitro.
in vitro is has also been shown that Angpt-2 can act as a dose-dependent Tie2 (显示 TEK ELISA试剂盒) agonist/antagonist.
Ang-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin (显示 INS ELISA试剂盒) resistance is detectable.
pathways for two distinctive secretory mechanisms, constitutive and stimulated, of Ang-2 in pulmonary microvascular endothelial cells.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (显示 ANGPT1 ELISA试剂盒) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (显示 HIF1A ELISA试剂盒) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)