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抗Mouse (Murine) Angiopoietin 2 抗体:
抗Human Angiopoietin 2 抗体:
抗Rat (Rattus) Angiopoietin 2 抗体:
Chicken Monoclonal Angiopoietin 2 Primary Antibody for ICC, IHC (fro) - ABIN259881
Laquer, Dao, Pavlis, Nguyen, Chen, Harris, Rugg, Kelly: Immunohistochemistry of angiogenesis mediators before and after pulsed dye laser treatment of angiomas. in Lasers in surgery and medicine 2012
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Human Polyclonal Angiopoietin 2 Primary Antibody for IF (p), IHC (p) - ABIN671781
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
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Human Polyclonal Angiopoietin 2 Primary Antibody for FACS, IHC (p) - ABIN654062
Morrissey, Dowell, Koreckij, Nguyen, Lakely, Fanslow, True, Corey, Vessella: Inhibition of angiopoietin-2 in LuCaP 23.1 prostate cancer tumors decreases tumor growth and viability. in The Prostate 2010
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Human Polyclonal Angiopoietin 2 Primary Antibody for IHC, IHC (p) - ABIN4280609
Zhou, Fang, Shang, Zhang, Sang, Xu, Yuan, Chen, Zheng, Zhang, Zhuang: MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. in The Journal of pathology 2016
Human Polyclonal Angiopoietin 2 Primary Antibody for WB - ABIN1043684
Davis, Aldrich, Jones, Acheson, Compton, Jain, Ryan, Bruno, Radziejewski, Maisonpierre, Yancopoulos: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. in Cell 1997
Mouse (Murine) Polyclonal Angiopoietin 2 Primary Antibody for WB - ABIN95113
Câmpean, Karpe, Haas, Atalla, Peters, Rupprecht, Liebner, Acker, Plate, Amann: Angiopoietin 1 and 2 gene and protein expression is differentially regulated in acute anti-Thy1.1 glomerulonephritis. in American journal of physiology. Renal physiology 2008
Shear stress activated Ang-2 via canonical Wnt (显示 WNT2 抗体) signaling in vascular endothelial cells, and Wnt (显示 WNT2 抗体)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (显示 TEK 抗体) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (显示 TEK 抗体) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (显示 TEK 抗体) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (显示 TIE1 抗体) in inflammation leads to ANG2 antagonism of Tie2 (显示 TEK 抗体) and initiates a positive feedback loop wherein FOXO1 (显示 FOXO1 抗体)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (显示 ANGPT1 抗体)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (显示 NME1 抗体) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (显示 MLXIP 抗体)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (显示 ANGPT1 抗体) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (显示 IL18 抗体) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
serum Ang-2 and Ang-1 (显示 ANGPT1 抗体) levels may help in the diagnosis of patients with lymphatic anomalies and are concordant to sirolimus response.
Studied role of change in ratio of angiopoietin-2 (Ang-2) to angiopoietin-1 (Ang-1 (显示 ANGPT1 抗体)) levels in hantavirus ionfections. Found imbalance in ang-2:ang-1 (显示 ANGPT1 抗体) lasted through the acute infection phase.
The relation between angiopoietin-2 and assessed parameters of vascular structure in type 1 diabetes reflects a state of endothelial injury and highlights the role of disturbed angiogenesis and vascular inflammation in the occurrence of diabetic complications.
Results show that MiR (显示 MLXIP 抗体)-93 targets Ang2 3' UTR (显示 UTS2R 抗体) and regulates its expression in lung adenocarcinoma.
We demonstrate that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (显示 TEK 抗体) receptor and partly directly via tumor cell surface integrin &1.
ANG2 did not affect apoptosis or the cell cycle. In contrast, in the in vivo system, overexpression of ANG2 increased tumor growth.
When Tie2 (显示 TEK 抗体) becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2 (显示 TEK 抗体), Angiopoietin-1 (显示 ANGPT1 抗体) and Angiopoietin-2, regulate its activation status.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (显示 IL6 抗体) (40.2pg/mL), VEGF-A (显示 VEGFA 抗体) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (显示 PRAP1 抗体) (248.1pg/mL), sHER-2/neu (显示 ERBB2 抗体) (5010pg/mL) and PLGF (显示 PGF 抗体) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Gab1 (显示 GAB1 抗体)/SHP2 (显示 PTPN11 抗体)/p38MAPK (显示 MAPK14 抗体) signaling pathway and Ang-2 have an essential role in regulating thrombin (显示 F2 抗体)-induced monocyte adhesion and vascular leakage
This study demonstrated that ANGPT2 higher expression in glioblastoma.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (显示 ANGPT1 抗体) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (显示 HIF1A 抗体) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN (显示 PTEN 抗体)/PI3-K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)