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Dog (Canine) Polyclonal SART3 Primary Antibody for IHC, WB - ABIN2780944
Liu, Li, Kim, Pace, He: HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Human Polyclonal SART3 Primary Antibody for ELISA, WB - ABIN250557
Bell, Schreiner, Damianov, Reddy, Bindereif: p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. in The EMBO journal 2002
Cow (Bovine) Polyclonal SART3 Primary Antibody for WB - ABIN2775728
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Data suggest that ZIP (显示 DAPK3 抗体), USP39 (显示 USP39 抗体), Prp24/p100/SART3, and Prp43 (显示 DHX15 抗体) associate to form complex instrumental in spliceosome assembly; ZIP (显示 DAPK3 抗体) regulates pre-mRNA splicing of USP39 (显示 USP39 抗体) independent of RNA binding; stable 35S tri (显示 VANGL2 抗体)-snRNP (显示 LSM2 抗体) particles are enriched in Cajal body. (ZIP (显示 DAPK3 抗体) = zinc finger and G-patch domain-containing protein (显示 ZGPAT 抗体); USP39 (显示 USP39 抗体) = ubiquitin specific peptidase 39 (显示 USP39 抗体); Prp43 (显示 DHX15 抗体) = RNA helicase (显示 DDX46 抗体) Prp43 (显示 DHX15 抗体))
We show that PRP31 (显示 PRPF31 抗体), a component of U4 snRNP (显示 LSM2 抗体), is modified with K63-linked ubiquitin chains by the PRP19 (显示 PRPF19 抗体) complex and deubiquitinated by USP15 (显示 USP15 抗体) and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 (显示 USP4 抗体) and this ternary complex serves as a platform to deubiquitinate PRP31 (显示 PRPF31 抗体) and PRP3 (显示 CLCA4 抗体)
The complex structure of SART3 nuclear localization signal (NLS (显示 ALDH1A2 抗体)) and importin-alpha reveals bipartite binding, and removal of SART3 NLS (显示 ALDH1A2 抗体) prevents the entry of USP4 (显示 USP4 抗体) (and USP15 (显示 USP15 抗体)) into the nucleus and abrogates the subsequent deubiquitinase activity of USP4 (显示 USP4 抗体).
crystal structures of SART3 in the apo (显示 C9orf3 抗体)-form and in complex with the DUSP (显示 DUSP5 抗体)-UBL domain of USP15 (显示 USP15 抗体) at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 contains 12 half-a-tetratricopeptide (HAT (显示 MGEA5 抗体)) repeats, organized into two subdomains, HAT (显示 MGEA5 抗体)-N and HAT (显示 MGEA5 抗体)-C. SART3 dimerizes through the concave surface of HAT (显示 MGEA5 抗体)-C, whereas the HAT (显示 MGEA5 抗体)-C convex surface binds USP15 (显示 USP15 抗体) in a novel bipartite mode.
miR (显示 MLXIP 抗体)-124 regulates Tip110 expression and differentiation of human cord blood CD34 (显示 CD34 抗体)(+) cells
Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome system. Under hypoxia, Tip110 stabilized p53 (显示 TP53 抗体), which in return destabilized Tip110.
SART3 recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15 (显示 USP15 抗体)
YB-1 (显示 YBX1 抗体) potentiates the Tip110/Tat (显示 TAT 抗体)-mediated transactivation of the HIV-1 LTR promoter.
findings show C-MYC (显示 MYC 抗体) upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 (显示 POU5F1 抗体) alternative splicing in hESCs
TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs (显示 NR2E3 抗体).
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
squamous cell carcinoma antigen recognized by T cells 3
, Squamous cell carcinoma antigen recognized by T-cells 3
, squamous cell carcinoma antigen recognized by T-cells 3-like
, earl grey
, squamous cell carcinoma antigen recognized by T-cells 3
, tat-interacting protein of 110 kDa
, tumor-rejection antigen SART3