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Identification and characterization a novel protein component of the survival of motor neurons complex termed Gemin7 using native purified SMN (显示 STMN1 ELISA试剂盒) complexes and peptide sequencing by mass spectrometry
Unrip (显示 STRAP ELISA试剂盒) is recruited to the active SMN (显示 STMN1 ELISA试剂盒) complex via a stable interaction with Gemin7
Gemin8 (显示 GEMIN8 ELISA试剂盒) has an essential role in the proper structural organization of the SMN (显示 STMN1 ELISA试剂盒) complex and the involvement of the heteromeric subunit containing Gemin6 (显示 GEMIN6 ELISA试剂盒), Gemin7, Gemin8 (显示 GEMIN8 ELISA试剂盒), and Unrip (显示 STRAP ELISA试剂盒) in the recruitment of Sm proteins to the snRNP (显示 LSM2 ELISA试剂盒) assembly pathway
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
gem (nuclear organelle) associated protein 7
, gem-associated protein 7
, gemin 7