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TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog (显示 SHH ELISA试剂盒) signaling pathway in ovarian cancer cells.
The cooperation between TRIM16 and Galectin-3 (显示 LGALS3 ELISA试剂盒) in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion.
TRIM16 expression is decreased in prostate cancer tissues and overexpression of TRIM16 inhibits cell migration, invasion and the EMT (显示 ITK ELISA试剂盒) process in vitro in prostate cancer through the transcription factor Snail (显示 SNAI1 ELISA试剂盒).
Results found that the expression of TRIM16 was significantly downregulated in hepatocellular carcinoma cell (HCC (显示 FAM126A ELISA试剂盒)) lesions and define TRIM16 as an inhibitor of epithelial-mesenchymal transition and metastasis in HCC (显示 FAM126A ELISA试剂盒).
TRIM16 directly regulated the degradation of Gli1 (显示 GLI1 ELISA试剂盒) protein via the ubiquitinproteasome pathway. TRIM16 expression was low in breast cancer. It negatively correlated with metastasis and suppressed stem-cell properties in breast cancer cells.
Data suggest that TRIM16 and TDP43 (显示 TARDBP ELISA试剂盒) are both good prognosis indicators; data shows that TRIM16 inhibits cancer cell viability by a novel mechanism involving interaction and stabilisation of TDP43 (显示 TARDBP ELISA试剂盒) with consequent effects on E2F1 (显示 E2F1 ELISA试剂盒) and pRb (显示 RB1 ELISA试剂盒) proteins.
Expression of SDMGC and TRIM16 was upregulated in the distant metastasis tissues
Chromatin immunoprecipitation assays revealed TRIM16 directly bound the IFNbeta1 gene promoter. Low level TRIM16 expression in 91 melanoma patient samples, strongly correlated with lymph node metastasis, and, predicted poor patient prognosis.
results suggest that TRIM16 is a potential pharmacologic target for the treatment of NSCLC and promotion TRIM16 expression might represent a novel strategy to NSCLC metastasis
TRIM16 can promote apoptosis by directly modulating caspase-2 (显示 CASP2 ELISA试剂盒) activity in cancer cells.
we demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice.
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
tripartite motif protein 16
, tripartite motif-containing 16
, tripartite motif-containing protein 16
, estrogen-responsive B box protein