ASXL1 (ASXL1) ELISA试剂盒产品概述

Full name:
Additional Sex Combs Like 1 (Drosophila) ELISA试剂盒 (ASXL1)
在www.antibodies-online.cn可供0 Additional Sex Combs Like 1 (Drosophila) (ASXL1) ELISA试剂盒的不同的供货商。 再加上,我们可以发ASXL1 抗体 (36)ASXL1 蛋白 (6)和数多这个蛋白质的别的产品。 总共43 ASXL1产品已列进来了。
别名:
asxl1, BOPS, MDS, MGC83850, mKIAA0978
list all ELISA KIts 基因 基因ID UniProt
小鼠 ASXL1 ASXL1 228790 P59598
 ASXL1 ASXL1 171023 Q8IXJ9

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适于 ASXL1 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. implicate Asxl1 in the maintenance of podocyte structure via its association with Wtip (显示 WTIP ELISA试剂盒) and in the regulation of WT1 (显示 WT1 ELISA试剂盒) signaling during early kidney development

  2. ASXL1 truncation mutations confer gain-of-function on the ASXL-BAP1 (显示 BAP1 ELISA试剂盒) complex.

  3. Asxl1-/- fetuses have reduced body weight and display cleft palate, anophthalmia as well as ventricular septal defects and a failure in lung maturation.

  4. Asxl1 functions as a tumor suppressor to maintain hematopoietic cell homeostasis

  5. C-terminal-truncating Asxl1 mutations inhibited myeloid differentiation and induced myelodysplastic syndrome-like disease

  6. Constitutive loss of Asxl1 results in developmental abnormalities, including anophthalmia, microcephaly, cleft palate, and mandibular malformations. Hematopoietic-specific deletion results in cytopenia and dysplasia with increased hematopoietic stem cells

  7. ASXL1 represses, whereas ASXL2 (显示 ASXL2 ELISA试剂盒) increases, the expression of adipogenic genes, most of which are PPARgamma (显示 PPARG ELISA试剂盒) targets

  8. Asxl1 is needed for normal hematopoiesis.

  9. Asxl1and Asxl2 (显示 ASXL2 ELISA试剂盒) are expressed as multiple transcripts, at varying levels, in adult tissues and in embryonic stem cells analyzed by Northern blot, and exhibit similar expression patterns suggesting they may be co-regulated

  10. ASXL1 is a novel coactivator of RAR (显示 RARA ELISA试剂盒) that cooperates with SRC-1 (显示 NCOA1 ELISA试剂盒)

Human Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. mutations in the SRSF2 (显示 SRSF2 ELISA试剂盒)/ASXL1/RUNX1 (显示 RUNX1 ELISA试剂盒) gene panel identified as significant prognostic markers in systemic mastocytosis

  2. It was found that the absence of mutations in the SRSF2 (显示 SRSF2 ELISA试剂盒), ASXL1, and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  3. Mutation in ASXL1 gene is associated with chronic myelomonocytic leukemia.

  4. ASXL1 mutation is associated with acute myeloid leukemia (显示 BCL11A ELISA试剂盒).

  5. We examined all ASXL1 truncating variants in the ExAC database and determined most are likely somatic. Failure to consider somatic mosaicism may lead to the inaccurate assumption that conditions like BOS have reduced penetrance, or the misclassification of potentially pathogenic variants.

  6. ASXL1 Circular RNA is Produced by Splicing from its pre-mRNA.

  7. We conclude that ASXL1 is essential for erythroid development and differentiation and that the aberrant differentiation is, at least in part, facilitated via PRC2.

  8. Demonstration of ASXL1 mutation, a putative tumor suppressor gene, represents an important molecular abnormality in CML (显示 BCR ELISA试剂盒). Authors also showed that concomitant detection of BCR-ABL (显示 ABL1 ELISA试剂盒) and JAK2V617F mutations has a relatively high incidence in Iranian patients.

  9. This study showed ASXL1 exon 12 mutations in 16 of 70 (23%) patients with myelofibrosis, with 11 different mutations found in these patients.

  10. Mutations in ASXL1, U2AF1 (显示 U2AF1 ELISA试剂盒), and SF3B1 are common in Chinese patients with myelodysplastic syndromes.

ASXL1 抗原简介

Antigen Summary

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with ASXL1

  • additional sex combs like 1 (Drosophila) (asxl1) Elisa Kit
  • additional sex combs like 1 (LOC100341931) Elisa Kit
  • additional sex combs like 1 (asxl1) Elisa Kit
  • additional sex combs like 1 (Asxl1) Elisa Kit
  • additional sex combs like 1 (Drosophila) (ASXL1) Elisa Kit
  • asxl1 Elisa Kit
  • BOPS Elisa Kit
  • MDS Elisa Kit
  • MGC83850 Elisa Kit
  • mKIAA0978 Elisa Kit

Protein level used designations for ASXL1

additional sex combs like 1 , additional sex combs-like protein 1 , putative Polycomb group protein ASXL1

GENE ID SPECIES
446414 Xenopus laevis
100341931 Oryctolagus cuniculus
100379981 Xenopus (Silurana) tropicalis
228790 Mus musculus
171023 Homo sapiens
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