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the Canoe Ras-association (RA) domains directly bind RanGTP
Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos
anillin (显示 ANLN ELISA试剂盒) and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
we demonstrated that DICER (显示 DICER1 ELISA试剂盒) (rs3742330) and RAN (rs14035) were associated with the survival of HCC (显示 FAM126A ELISA试剂盒) patients
RAN translation from antisense CCG repeats generates novel proteins that accumulate in ubiquitinated inclusions in Fragile X-associated tremor/ataxia syndrome patients.
Binding of Ran to NTF2 (显示 NUTF2 ELISA试剂盒) is required for NTF2 (显示 NUTF2 ELISA试剂盒) to inhibit nuclear expansion and import of large cargo molecules.
FGF2 (显示 FGF2 ELISA试剂盒) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells
Enterovirus 71-induced downregulation of miR (显示 MLXIP ELISA试剂盒)-197 expression increased the expression of RAN, which supported the nuclear transport of the essential viral proteins 3D/3CD and host protein hnRNP K (显示 HNRNPK ELISA试剂盒) for viral replication.
Inter-cellular transport of ran GTPase
Data show that RNA-binding protein (显示 PTBP1 ELISA试剂盒) LIN28B (显示 LIN28B ELISA试剂盒) coordinates the expression of the oncogene (显示 RAB1A ELISA试剂盒) RAN protein and aurora A kinase (AURKA (显示 AURKA ELISA试剂盒)) in neuroblastoma (显示 ARHGEF16 ELISA试剂盒).
Elevated metaphase RanGTP levels use Ubr5 (显示 UBR5 ELISA试剂盒) to couple overall chromosome congression to SAC (显示 ADCY10 ELISA试剂盒) silencing.
Data show that importin-beta (显示 KPNB1 ELISA试剂盒) (impbeta) alters the nuclear pore's permeability in a Ran-dependent manner, suggesting that impbeta is a functional component of the nuclear pore complex (NPC (显示 NPC1 ELISA试剂盒)).
Data suggest Ran activation by RanBP1 (显示 RANBP1 ELISA试剂盒) in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Augmented expression of Ran in progranulin (显示 GRN ELISA试剂盒)-deficient neurons restores nuclear TDP-43 (显示 TARDBP ELISA试剂盒) levels and improves their survival.
Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells.
a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 (显示 SMOC2 ELISA试剂盒) that has important consequences for oncogenic transformation.
A critical function of RanBP2 (显示 RANBP2 ELISA试剂盒) is to capture recycling RanGTP-importin-beta (显示 KPNB1 ELISA试剂盒) complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.
Downregulation of the Ran GTPase effector RanBP1 (显示 RANBP1 ELISA试剂盒) is required for nuclear reorganisation.
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
intracellular Ran protein levels control the nuclear retention for selective transcription factors such as c-Jun (显示 JUN ELISA试剂盒) and c-Fos of AP-1 (显示 JUN ELISA试剂盒), which is known to be critical in T cell activation and proliferation and lymphokine (显示 IL2 ELISA试剂盒) secretion.
expression of Ran/M1 (显示 TLR4 ELISA试剂盒) and Ran/M2 increased in pachytene spermatocytes with progressive transcript accumulation until they reached the round spermatid stage, in the seminiferous epithelium of adults
RanGDP is regulated by phosphorylation and regulated by NTF2 (显示 NUTF2 ELISA试剂盒)
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
GTP-binding nuclear protein Ran
, GTPase Ran
, ras-like protein TC4
, ras-related nuclear protein
, RAN, member RAS oncogene family
, ran GTP-binding protein
, Ran GTPase
, androgen receptor-associated protein 24
, guanosine triphosphatase Ran
, member RAS oncogene family
, RAN, member RAS oncogene family pseudogene 1
, GTP-binding nuclear protein Ran, testis-specific isoform
, RAS-like, family 2, locus 9, pseudogene