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MIF was found to be essential for axis formation and neural development of Xenopus embryos.
Data show that the mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG (显示 SAG 蛋白)) development, and lateral line HC differentiation.
Gene expression of MIF was 30-fold higher in the heart, compared to skeletal muscle and protein expression of MIF was 3-fold higher in the heart compared to skeletal muscle.
renal tubular MIF is an endogenous renoprotective factor in progressive kidney diseases
locally produced MIF in the inflammatory bone lytic site is engaged in the chemoattraction of circulating CXCR4 (显示 CXCR4 蛋白)+ osteoclast precursor cells.
MIF expression was induced in chondrocytes of tissue-engineered cartilage, and could exert a profound effect on chondrocytes by promoting cartilage maturation. MIF could also regulate the phenotype of surrounding macrophages, impairing the maturation of transplanted tissues.
loss of autophagy, by pharmacological inhibition or siRNA silencing of Atg5 (显示 ATG5 蛋白), enhances MIF secretion by monocytes and macrophages.
CHD7 is an important factor in the proliferation and stemness maintenance of neural stem/progenitor cells.
MIF-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (显示 GATA3 蛋白) expression and interleukin-13 (显示 IL13 蛋白) production in the mesenteric lymph nodes
Sertoli cells to produce MIF under normal conditions. MIFR (显示 MMP23B 蛋白) is expressed in GFRalpha1 (显示 GFRA1 蛋白) and Sertoli cells. MIF induced spermatogonial cell migration
MIF-transgenic cells exhibited substantially decreased levels of p53 (显示 TP53 蛋白) after hyperthermia treatment compared with WT and MIF-knockout cells
recombinant macrophage migration inhibitory factor is important for the synthesis of il1beta (显示 IL1B 蛋白) mRNA in vivo and in isolated macrophages.
The assay monitors the increase in absorbance at 320 nm resulting from keto-to-enol tautomerization of 4-hydroxyphenylpyruvate, a reaction catalyzed by MIF (显示 AMH 蛋白). We ran a full-diversity screen evaluating the inhibitory activity of 1.6 million compounds.
The rs5844572 polymorphism in MIF (显示 AMH 蛋白) is linked to the rate of progression and extent of fibrosis in Biliary Atresia Patients, but not with disease susceptibility.
Absolute numbers of MIF (显示 AMH 蛋白) and IL-1beta (显示 IL1B 蛋白) mRNA molecules are both accurate and reliable predictors of antidepressant response.
The knockdown of D-DT and MIF (显示 AMH 蛋白), individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor.
No association between coronary artery disease class and -794 CATT5-8 MIF polymorphisms with soluble MIF levels in CAD subjects.
These results have implications for the manner in which D-DT and MIF (显示 AMH 蛋白) compete with each other for binding to the CD74 (显示 CD74 蛋白) receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF (显示 AMH 蛋白) binding and activation through CD74 (显示 CD74 蛋白).
Plasma MIF (显示 AMH 蛋白) was elevated after cardiac stress (relative to before stress) in patients with a positive stress test, compared with those with a negative stress test. Plasma MIF (显示 AMH 蛋白) is an early marker for myocardial ischemia. MIF (显示 AMH 蛋白) was not altered after exercise in peripheral arterial occlusive disease patients, despite the occurrence of claudication, suggesting that plasma MIF (显示 AMH 蛋白) is not a marker for skeletal muscle ischemia.
Increased serum MIF concentrations have close relation to inflammation, trauma severity and clinical outcomes, substantializing MIF as a good prognostic biomarker after TBI
renal tubular MIF (显示 AMH 蛋白) is an endogenous renoprotective factor in progressive kidney diseases
MIF (显示 AMH 蛋白) is primarily an indirect promoter of glioblastoma progression.
plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows
Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves.
The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity.
MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions
The diverse actions of MIF within the immuno-neuroendocrine system may be a result of its occurrence in different isoforms and oligomerization states.
The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported.
Transcription of MIF is induced by activation of PPARgamma2 (显示 PPARG 蛋白) and inhibited by excessive resistin (显示 RETN 蛋白).
The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
, L-dopachrome tautomerase
, Phenylpyruvate tautomerase
, macrophage migration inhibitory factor
, phenylpyruvate tautomerase
, Macrophage migration inhibitory factor
, delayed early response protein 6
, glycosylation-inhibiting factor
, glutathione-binding 13 kDa protein