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MIF was found to be essential for axis formation and neural development of Xenopus embryos.
Data show that the mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG (显示 SAG 蛋白)) development, and lateral line HC differentiation.
MIF expression was induced in chondrocytes of tissue-engineered cartilage, and could exert a profound effect on chondrocytes by promoting cartilage maturation. MIF could also regulate the phenotype of surrounding macrophages, impairing the maturation of transplanted tissues.
loss of autophagy, by pharmacological inhibition or siRNA silencing of Atg5 (显示 ATG5 蛋白), enhances MIF secretion by monocytes and macrophages.
CHD7 is an important factor in the proliferation and stemness maintenance of neural stem/progenitor cells.
MIF-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (显示 GATA3 蛋白) expression and interleukin-13 (显示 IL13 蛋白) production in the mesenteric lymph nodes
Sertoli cells to produce MIF under normal conditions. MIFR (显示 MMP23B 蛋白) is expressed in GFRalpha1 (显示 GFRA1 蛋白) and Sertoli cells. MIF induced spermatogonial cell migration
MIF-transgenic cells exhibited substantially decreased levels of p53 (显示 TP53 蛋白) after hyperthermia treatment compared with WT and MIF-knockout cells
recombinant macrophage migration inhibitory factor is important for the synthesis of il1beta (显示 IL1B 蛋白) mRNA in vivo and in isolated macrophages.
MIF-CD74 (显示 CD74 蛋白) signaling inhibits interferon (IFN)-gamma (显示 IFNA 蛋白) secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF signaling or its receptor CD74 (显示 CD74 蛋白) promotes IFN-gamma (显示 IFNG 蛋白) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.
This study showed that loss of keratinocyte-derived MIF leads to a loss of control of epithelial skin tumor formation in chemical skin carcinogenesis, which highlights an unexpected tumor-suppressive activity of MIF in murine skin.
This study was undertaken to investigate the potential role of Macrophage migration inhibitory factor in osteoarthritis in human joint tissues and in vivo in mice with age-related and surgically induced osteoarthritis
Data highlight the complexity of the MIF (显示 AMH 蛋白)/CD74 (显示 CD74 蛋白) signaling pathway in the development of mesothelioma.
increased nuclear-expressed MIF (显示 AMH 蛋白) under hypoxia was identified to act as a transcriptional regulator by interacting with the promoter of SOX9 (显示 SOX9 蛋白) and RUNX2 (显示 RUNX2 蛋白).
MIF (显示 AMH 蛋白) expression was induced in chondrocytes of tissue-engineered cartilage, and could exert a profound effect on chondrocytes by promoting cartilage maturation. MIF (显示 AMH 蛋白) could also regulate the phenotype of surrounding macrophages, impairing the maturation of transplanted tissues.
loss of autophagy, by pharmacological inhibition or siRNA silencing of Atg5 (显示 ATG5 蛋白), enhances MIF (显示 AMH 蛋白) secretion by monocytes and macrophages.
The function of the binding between MIF (显示 AMH 蛋白) and HTRA1 (显示 HTRA1 蛋白) is to inhibit the proteolytic activity of HTRA1 (显示 HTRA1 蛋白).
MIF (显示 AMH 蛋白) is a target of miR (显示 MLXIP 蛋白)-451 in NSCLC cells.
MIF (显示 AMH 蛋白) could activate the osteosarcoma RAS/MAPK (显示 MAPK1 蛋白) pathway in a time- and dose-dependent manner, thereby promoting cell proliferation, migration and lung metastasis.
MIF (显示 AMH 蛋白)-CD74 (显示 CD74 蛋白) signaling inhibits interferon (IFN)-gamma (显示 IFNA 蛋白) secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (显示 AMH 蛋白) signaling or its receptor CD74 (显示 CD74 蛋白) promotes IFN-gamma (显示 IFNG 蛋白) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.
The -794 7-CATT locus and the MIF C/7-CATT haplotype were significantly associated with decreased total IgE levels in the plasma, suggesting that these polymorphisms might be a marker for intrinsic atopic dermatitis rather than extrinsic atopic dermatitis.
our findings suggest that MIF (显示 AMH 蛋白) regulates brain tumor-initiating cells function through direct, intracellular inhibition of p53 (显示 TP53 蛋白), shedding light on the molecular mechanisms underlying the tumorigenicity of certain malignant brain cells.
plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows
Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves.
The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity.
MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions
The diverse actions of MIF within the immuno-neuroendocrine system may be a result of its occurrence in different isoforms and oligomerization states.
The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported.
Transcription of MIF is induced by activation of PPARgamma2 (显示 PPARG 蛋白) and inhibited by excessive resistin (显示 RETN 蛋白).
The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
, L-dopachrome tautomerase
, Phenylpyruvate tautomerase
, macrophage migration inhibitory factor
, phenylpyruvate tautomerase
, Macrophage migration inhibitory factor
, delayed early response protein 6
, glycosylation-inhibiting factor
, glutathione-binding 13 kDa protein