anti-PTBP1 (PTBP1) 抗体产品概述

Full name:
anti-Polypyrimidine Tract Binding Protein 1 抗体 (PTBP1)
在www.antibodies-online.cn可供93 Polypyrimidine Tract Binding Protein 1 (PTBP1) 抗体的21不同的供货商。 再加上,我们可以发PTBP1 蛋白 (12)PTBP1 试剂盒 (7)和数多这个蛋白质的别的产品。 总共123 PTBP1产品已列进来了。
别名:
AA407203, AL033359, ATPTB1, HNRNP-I, HNRNPI, HNRPI, POLYPYRIMIDINE TRACT-BINDING, polypyrimidine tract-binding protein 1, pPTB, ptb, PTB-1, PTB-T, PTB2, PTB3, PTB4, ptbp1, Pybp, Pybp1, Pybp2, T4P13.16, T4P13_16, vgrbp60, wu:fb99f12, zgc:110689
列出全部抗体 基因 基因ID UniProt
PTBP1 302879  
PTBP1 5725 P26599
PTBP1 19205  

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  1. Human Polyclonal PTBP1 Primary Antibody for WB - ABIN1881702 : Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010 (PubMed)
    Show all 5 references for 1881702

  2. Human Polyclonal PTBP1 Primary Antibody for IHC (p), IHC - ABIN250017 : Cote, Zhu, Thomas, Martin, Murad, Sharina: Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. in PLoS ONE 2012 (PubMed)
    Show all 2 references for 250017

  3. Cow (Bovine) Polyclonal PTBP1 Primary Antibody for WB - ABIN2778815 : Somberg, Zhao, Fröhlich, Evander, Schwartz: Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632. in Journal of virology 2008 (PubMed)
    Show all 2 references for 2778815

  4. Human Polyclonal PTBP1 Primary Antibody for IHC, ELISA - ABIN185079 : Charlet-B, Logan, Singh, Cooper: Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. in Molecular cell 2002 (PubMed)

  5. Cow (Bovine) Polyclonal PTBP1 Primary Antibody for WB - ABIN2778814 : Robinson, Smith: A splicing repressor domain in polypyrimidine tract-binding protein. in The Journal of biological chemistry 2006 (PubMed)

更多抗PTBP1的相互作用对抗体

Xenopus laevis Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.

  2. Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon

Human Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. Studied interactions of polypyrimidine tract-binding protein (PTBP1), pyruvate kinase M2 (PKM2), and STAT3 (signal transducer and activator of transcription 3 (显示 STAT3 抗体)) in oncogenesis of anaplastic large cell lymphoma (ALCL). Results show that in ALCL cells, PTBP1 is crucial for PKM2 phosphorylation of STAT3 (显示 STAT3 抗体) in the nucleus.

  2. Expression of ATG10 (显示 ATG10 抗体) negatively regulated by PTBP1 and is associated with metastasis of colorectal cancer cells.

  3. Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (显示 PCBP2 PLURAL_@28810@) (hnRNP (显示 HNRNPC PLURAL_@28810@)) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm.

  4. follow-up molecular analyses of one splicing factor (显示 SLU7 抗体) PTBP1 revealed its impact on disease-associated splicing patterns in Huntington's disease (HD). Collectively, our data provide genomic evidence for widespread splicing dysregulation in HD brains, and suggest the role of aberrant alternative splicing in the pathogenesis of HD

  5. CD5 (显示 CD5 抗体) transcription is increased, leading to the production of three mRNA isoforms by APA (显示 ENPEP 抗体), all contributing for protein production, at different levels. PTBP1 binds in the vicinity of pA1 (显示 PAGR1 抗体), leading to an increase in mRNA levels and miR (显示 MLXIP 抗体)-204 targets the longer CD5 (显示 CD5 抗体) mRNA.

  6. Increased expression of microRNA miR (显示 MLXIP 抗体)-145 combined with knockdown of PTBP1 protein contributed to the greater and longer growth suppression compared with each single treatment.

  7. MiR-133b switched the PKM isoform expression from PKM2 to PKM1 through the silencing of PTBP1, which is an alternative splicer of PKM, leading to growth suppression through the induction of autophagy in part by the metabolic switching from glycolysis to oxidative phosphorylation for a short period of time.

  8. Results suggested that PTBP1 and PTBP1-associated miR-1 and -133b are crucial molecules for the maintenance of the Warburg effect in colorectal tumors.

  9. The polypyrimidine tract binding protein 1 (PTBP1) shields specific retroviral and cellular transcripts from nonsense-mediated mRNA decay.

  10. findings point to PKM2 and PTBP1 as new potential therapeutic targets to improve response of PDAC to chemotherapy

Mouse (Murine) Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. Results indicate that heterogeneous nuclear ribonucleoprotein I (hnRNPI) plays a critical role in establishing neonatal immune adaptation and preventing colitis and colorectal cancer.

  2. Thus, PTBP1 controls the activity of Pbx1 (显示 PBX1 抗体) to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.

  3. showed polypyrimidine tract binding protein (PTBP)-dependent alternative splicing of CaMKIIalpha (显示 CAMK2 抗体) transcripts in the lens

  4. This may account for the tight correlation between Hps1 with Ptbp1 expression levels observed across mammalian tissues.

  5. The expression levels of three splicing factors, ESRP1 (显示 ESRP1 抗体), PTB and SF2/ASF (显示 SRSF1 抗体), are significantly altered during cardiac hypertrophy in mice.

  6. Study reports that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR (显示 MLXIP 抗体)-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons.

  7. The polypyrimidine tract binding proteins PTBP1 and PTBP2 (显示 PTBP2 抗体) repressed Psd-95 (显示 DLG4 抗体) (also known as Dlg4 (显示 DLG4 抗体)) exon 18 splicing, leading to premature translation termination and nonsense-mediated mRNA decay.

  8. PTBP1 is not required for the earliest isovolumetric divisions and differentiation steps of the zygote up to the formation of the blastocyst.

  9. RBM4 (显示 RBM4 抗体) may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTB expression and antagonizing the activity of PTB in exon selection

  10. splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression

Zebrafish Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. Data report on a zebrafish maternal-effect (显示 NLRP5 抗体) mutant, brom bones, which is defective in the cytosolic Ca(2 (显示 CA2 抗体)+) rise and subsequent egg activation events, including cortical granule exocytosis and cytoplasmic segregation [brom bones].

  2. Two stretches of polypyrimidine tracts designated PPT1 and PPT2 which influence the IRES activity of cx55.5 protein were identified; deletion of PPT1 results in an appreciable decrease of the IRES activity

Arabidopsis thaliana Polypyrimidine Tract Binding Protein 1 (PTBP1) interaction partners

  1. PTB1 is a splicing factor (显示 SLU7 抗体) that influences alternative splicing and acts at the polypyrimidine tract.

  2. Alternative splicing (AS) patterns as well as the expression of key flowering regulators were massively changed in a PTB1/2 level-dependent manner.

  3. AtPTB1 and AtPTB2 are widely expressed in almost all tissues, with the highest expression levels in late-maturing and mature pollen grains, and are crucial for pollen germination. [AtPTB1]

PTBP1 抗原简介

Antigen Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with PTBP1

  • polypyrimidine tract binding protein 1 (ptbp1-b) 抗体
  • polypyrimidine tract-binding protein (Smptb) 抗体
  • polypyrimidine tract-binding protein (NAEGRDRAFT_80143) 抗体
  • polypyrimidine tract-binding protein (LOC100285404) 抗体
  • polypyrimidine tract binding protein 1 (PTBP1) 抗体
  • polypyrimidine tract binding protein 1 (ptbp1-a) 抗体
  • polypyrimidine tract binding protein 1 (Ptbp1) 抗体
  • polypyrimidine tract binding protein 1a (ptbp1a) 抗体
  • polypyrimidine tract-binding protein 1 (PTB1) 抗体
  • AA407203 抗体
  • AL033359 抗体
  • ATPTB1 抗体
  • HNRNP-I 抗体
  • HNRNPI 抗体
  • HNRPI 抗体
  • POLYPYRIMIDINE TRACT-BINDING 抗体
  • polypyrimidine tract-binding protein 1 抗体
  • pPTB 抗体
  • ptb 抗体
  • PTB-1 抗体
  • PTB-T 抗体
  • PTB2 抗体
  • PTB3 抗体
  • PTB4 抗体
  • ptbp1 抗体
  • Pybp 抗体
  • Pybp1 抗体
  • Pybp2 抗体
  • T4P13.16 抗体
  • T4P13_16 抗体
  • vgrbp60 抗体
  • wu:fb99f12 抗体
  • zgc:110689 抗体

Protein level used designations for PTBP1

polypyrimidine tract binding protein 1 , hnrnp I , hnRNP I-related RNA transport protein VgRBP60 , polypyrimidine tract-binding protein , PTB , polypyrimidine tract-binding protein 1 , 57 kDa RNA-binding protein PPTB-1 , RNA-binding protein , heterogeneous nuclear ribonucleoprotein I , heterogeneous nuclear ribonucleoprotein polypeptide I , hnRNP I , polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) , pyrimidine binding protein 1 , pyrimidine binding protein 2 , brb , brom bones

GENE ID SPECIES
399134 Xenopus laevis
302879 Rattus norvegicus
8853259 Naegleria gruberi strain NEG-M
100285404 Zea mays
282018 Bos taurus
5725 Homo sapiens
379861 Xenopus laevis
485097 Canis lupus familiaris
397461 Sus scrofa
19205 Mus musculus
29497 Rattus norvegicus
323490 Danio rerio
821129 Arabidopsis thaliana
420098 Gallus gallus
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