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Pitx2c expression is rea (显示 PITX2 ELISA试剂盒)ctivated, while expression of Myf5 is downregulated in human systolic heart failure as determined by qRT-PCR and Western blot analyses.
results are the first demonstration of a myogenic conversion of human mesenchymal and endothelial cells by Myf5
DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy
The myogenic basic helix-loop-helix family of transcription factors, MyoD (显示 MYOD1 ELISA试剂盒), Myf5, myogenin (显示 MYOG ELISA试剂盒), and MRF4 (显示 MYF6 ELISA试剂盒), can each activate the muscle differentiation program.
Mrf4 (显示 MYF6 ELISA试剂盒) expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis
Myogenin (显示 MYOG ELISA试剂盒) and myogenic differentiation factor D (MyoD (显示 MYOD1 ELISA试剂盒)) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (显示 MYOG ELISA试剂盒) (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 (显示 MYF6 ELISA试剂盒) protein increased (P < 0.05) in both young and old.
A novel homozygous polymorphism that prevented the binding of MYF-5 to FOXE1 (显示 FOXE1 ELISA试剂盒) promoter and affected the FOXE1 (显示 FOXE1 ELISA试剂盒) expression was found in 45% nonsyndromic cleft palate.
Novel RNA-binding activity of MYF5 enhances Ccnd1 (显示 CCND1 ELISA试剂盒) mRNA translation during myogenesis.
Transcription of the skeletal muscle program is achieved by the expression of MyoD (显示 MYOD1 ELISA试剂盒), which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites
The Myf5- and Myogenin (显示 MYOG ELISA试剂盒)-deficient mice showed a partial or complete, respectively, loss of TMC (显示 STT3A ELISA试剂盒) in an otherwise regularly structured thymus.
Elimination of Myf5(Cre)-DTA cells on a Myod (显示 MYOD1 ELISA试剂盒) null background did not result in the total absence of skeletal muscles
A muscle-specific (显示 EIF3K ELISA试剂盒) regulatory element of p57(kip2 (显示 CDKN1C ELISA试剂盒)) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch (显示 NOTCH1 ELISA试剂盒) targets Hes1/Hey1 (显示 HEY1 ELISA试剂盒) in progenitor cells, is identified.
lineage tracing based on multiple reporter lines has demonstrated that regardless of common ancestral expression of Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages
The results demonstrate the heterogeneity and functional differences of the Myf5- and non-Myf5-lineage cells in the white adipose tissue.
Adult satellite cells derive from progenitors that first express the myogenic determination gene Myf5 during fetal stages of myogenesis.
Direct molecular regulation of the myogenic determination gene Myf5 by Pax3 (显示 PAX3 ELISA试剂盒), with modulation by Six1 (显示 SIX1 ELISA试剂盒)/4 factors, is exemplified by the -111 kb-Myf5 enhancer
The observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5 haploinsufficiency.
Loss of Myf5 function results in a cascade effect that begins with abnormal formation of the dorsal organizer during gastrulation, causing defects in myf5-knockdown embryos
the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protein level of phosphorylated p38a (显示 MAPK14 ELISA试剂盒) and activates myf5 promoter activity of zebrafish embryos during myogenesis.
a novel intronic microRNA, miR (显示 MYLIP ELISA试剂盒)-In300, which is derived from I300 of the first intron of zebrafish myf5, enables significant repression of myf5 promoter activity through silencing the long isoform of the Dickkopfs-3 gene.
A novel regulatory base sequence functions as a key element to drive the somite-specificity of myf-5.
Functional analysis of intron 1 showed a strong, negative, cis (显示 CISH ELISA试剂盒)-regulatory element located at +502/+835, and this is the first study to identify a novel, cis (显示 CISH ELISA试剂盒)-acting silencer that is crucial to negatively regulating myf-5 expression.
Foxd3 (显示 FOXD3 ELISA试剂盒), a well-known regulator in neural crest development, is also involved in myf5 regulation
Myf5 and Myod (显示 MYOD1 ELISA试剂盒) function independently during cranial myogenesis.
cell lineage-specific expression of myf5 is delicately orchestrated by multiple modules within the distal upstream region. This study provides an insight to understand the molecular control of myf5 and myogenesis in the zebrafish.
The effects of myostatin (显示 MSTN ELISA试剂盒) and myogenic factor 5 polymorphisms on growth and muscle traits of Marchigiana breed were assessed.
Bos taurus MYF5 activates MYF5 and MYOD1 (显示 MYOD1 ELISA试剂盒) expression in cultured fibroblasts.
A polymorphism showed an influence on Myf5 gene expression in the longissimus dorsi muscle
results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles
myf5 upregulation can be a good criterion for the activation of adult myogenesis during X. laevis metamorphosis
During early Xenopus development Myf5 protein regulates a distinct myogenic program.
FGF8 (显示 FGF8 ELISA试剂盒), Wnt8 (显示 WNT8A ELISA试剂盒) and Myf5 are target genes of Tbx6 (显示 TBX6 ELISA试剂盒) during anteroposterior specification in Xenopus embryo
Exons and promoters are amplified and sequenced in the 5'UTR (显示 UTS2R ELISA试剂盒) region of this gene.
the novel SNP of the MYF5 gene within exon 1 is valuable for pig breeding.
The expression of Pitx2c (显示 PITX2 ELISA试剂盒), physiologically downregulated in the postnatal heart, is significantly re-activated in left ventricular failing myocardium which is associated with increased expression of a restrictive set of Pitx2 (显示 PITX2 ELISA试剂盒) target genes such as myf5.
Of the eight adult pig tissue types that were tested, the expression of Myf5 and MyoD1 (显示 MYOD1 ELISA试剂盒) was highest in the muscle tissue.
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
class C basic helix-loop-helix protein 2
, myogenic regulatory factor MYF-5
, myogenic regulatory factor 5
, Myf5 homolog
, myogenic factor 5
, MyoD family
, myogenic factor-5
, basic helix-loop-helix nuclear protein
, myogenic factor Xmyf-5