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Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (显示 LIMS1 ELISA试剂盒), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
PINCH (显示 LIMS1 ELISA试剂盒) and ILK have an independent capacity to localize at muscle attachment sites in vivo.
ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (显示 POSTN ELISA试剂盒) activation of signaling pathways involved in cyst growth and fibrosis in PKD (显示 PRKD1 ELISA试剂盒).
Ilk and ELMO2 (显示 ELMO2 ELISA试剂盒) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin (显示 CDH1 ELISA试剂盒)-based adherens junctions.
Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices.
It was concluded that ILK depletion modifies the transcription of GLUT4 (显示 SLC2A4 ELISA试剂盒), which results in reduced peripheral insulin (显示 INS ELISA试剂盒) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (显示 INS ELISA试剂盒) resistance.
results demonstrate that TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced autophagy links beta-catenin (显示 CTNNB1 ELISA试剂盒) and Smad (显示 SMAD1 ELISA试剂盒) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 ELISA试剂盒)/p-Smad2 (显示 SMAD2 ELISA试剂盒)/ILK pathway.
ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.
Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.
iNOS (显示 NOS2 ELISA试剂盒)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.
Hepatic ILK deletion has no effect on insulin (显示 INS ELISA试剂盒) action in lean mice but sensitizes the liver to insulin (显示 INS ELISA试剂盒) during the challenge of high fat feeding. This effect corresponds to changes in the expression and activation of key insulin (显示 INS ELISA试剂盒) signaling pathways as well as a greater capacity for hepatic mitochondrial glucose oxidation.
this study has identified a new role for Parvin (显示 PARVA ELISA试剂盒) and alphaPix (显示 ARHGEF6 ELISA试剂盒) downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation.
Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.
The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.
Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.
ILK aids trophoblast syncytialization via downregulation of CDH1 (显示 CDH1 ELISA试剂盒), perhaps through an ILK-PARP1 (显示 PARP1 ELISA试剂盒)-SNAI1 (显示 SNAI1 ELISA试剂盒) pathway
Emodin inhibits the migration and invasion abilities of human endometrial stromal cells by by facilitating the mesenchymal-epithelial transition through targeting integrin-linked kinase.
KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes.
Data indicate a regulatory role for tetraspanin 8 (Tspan8 (显示 TSPAN8 ELISA试剂盒)) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 (显示 TSPAN8 ELISA试剂盒) as a negative regulator of ILK activity.
Overexpression of ILK therefore promoted the proliferation of SHG44 human glioma cells, reduced apoptosis and reduced sensitivity to TMZ via decreasing the activity of caspase3.
Using in vitro studies, we demonstrated that ILK and PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) inhibitors suppressed the contraction of fibroblast-populated collagen lattices, inhibited fibroblast migration, and interrupted the effect of TGF-beta1 (显示 TGFB1 ELISA试剂盒) on promoting alpha smooth muscle actin (显示 ACTG2 ELISA试剂盒) (alpha-SMA (显示 SMN1 ELISA试剂盒)) expression in fibroblasts.
During human endometrial decidualization, ILK is essential for morphologic transformation of endometrial stromal cells through organization of the actin cytoskeleton.
Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Profilin (显示 PFN1 ELISA试剂盒)-dependent dissociation of G-actin (显示 ACTB ELISA试剂盒)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, Integrin-linked kinase
, integrin linked kinase
, integrin-linked protein kinase
, integrin-linked kinase
, Integrin-linked protein kinase
, integrin binding protein kinase
, main squeeze
, beta-integrin-linked kinase
, 59 kDa serine/threonine-protein kinase
, integrin-linked kinase-2