anti-HEY2 (HEY2) 抗体产品概述

Full name:
anti-Hairy/enhancer-of-Split Related with YRPW Motif 2 抗体 (HEY2)
在www.antibodies-online.cn可供71 Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) 抗体的16不同的供货商。 再加上,我们可以发HEY2 蛋白 (6)和数多这个蛋白质的别的产品。 总共85 HEY2产品已列进来了。
别名:
bHLHb32, CHF1, GRIDLOCK, grl, Herp1, hesr2, Hrt2, zgc:136746

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引用最多的anti-HEY2 抗体

  1. Zebrafish (Danio rerio) Polyclonal HEY2 Primary Antibody for WB - ABIN1881411 : Winkler, Elmasri, Klamt, Volff, Gessler: Characterization of hey bHLH genes in teleost fish. in Development genes and evolution 2003 (PubMed)
    Show all 3 references for 1881411

  2. Cow (Bovine) Polyclonal HEY2 Primary Antibody for WB - ABIN2780874 : Tang, Urs, Liaw: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. in Circulation research 2008 (PubMed)

更多抗HEY2的相互作用对抗体

Human Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall.

  2. Individuals with HEY2 duplications should be screened for congenital heart defects.

  3. HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current.

  4. Overexpression of HEY1 (显示 HEY1 抗体) and HEY2 in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.

  5. bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (显示 HEY1 抗体) and Hey2 gene expression within the first few hours after medium change

  6. a new HRD1 (显示 SYVN1 抗体)-associated membrane protein named HERP2 (显示 HEY1 抗体), which is homologous to the previously identified HRD1 (显示 SYVN1 抗体) partner HERP1. Despite sequence homology, HERP2 (显示 HEY1 抗体) is constitutively expressed in cells, whereas HERP1 is highly induced by ER stress.

  7. Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch (显示 NOTCH1 抗体) activity and HEY2 expression.

  8. Common variants at SCN5A (显示 SCN5A 抗体)-SCN10A (显示 SCN10A 抗体) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

  9. Hey2 and COUP-TFII (显示 NR2F2 抗体) have an important role in arteriovenous differentiation of human endothelial cells.

  10. Report down-regulation of Notch (显示 NOTCH1 抗体) signaling components NOTCH3 (显示 NOTCH3 抗体) and HEY2 in abdominal aortic aneurysms.

Mouse (Murine) Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Hey proteins mechanistically repress target genes via histone deacetylase (显示 HDAC1 抗体) recruitment and histone deacetylation.

  2. Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2

  3. Hey1 (显示 HEY1 抗体) and Hey2 in endothelial cells play important roles in vascular development.

  4. findings indicate that Hey1 (显示 HEY1 抗体) and Hey2 control the spatial and temporal pattern of auditory HC differentiation.

  5. CHF1/Hey2 may contribute to Brugada syndrome.

  6. Common variants at SCN5A (显示 SCN5A 抗体)-SCN10A (显示 SCN10A 抗体) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

  7. Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice.

  8. Data indicate that Notch1 (显示 NOTCH1 抗体) and Notch2 (显示 NOTCH2 抗体) are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch (显示 NOTCH1 抗体)-inducible genes, Hes1 and Hey2, was elevated in LRCs.

  9. Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle.

  10. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6 (显示 FKBP1B 抗体).

Zebrafish Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. essential role for Hey2 upstream of Notch in hematopoietic stem cell formation

  2. Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.

  3. The snrk (显示 SNRK 抗体)-1 gene acts downstream or parallel to notch (显示 NOTCH1 抗体) and upstream of gridlock during artery-vein specification

HEY2 抗原简介

Antigen Summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Alternative names and synonyms associated with HEY2

  • hairy/enhancer-of-split related with YRPW motif 2 (HEY2) 抗体
  • hairy/enhancer-of-split related with YRPW motif 2 (Hey2) 抗体
  • hairy/enhancer-of-split related with YRPW motif 2 (hey2) 抗体
  • bHLHb32 抗体
  • CHF1 抗体
  • GRIDLOCK 抗体
  • grl 抗体
  • Herp1 抗体
  • hesr2 抗体
  • Hrt2 抗体
  • zgc:136746 抗体

Protein level used designations for HEY2

hairy/enhancer-of-split related with YRPW motif protein 2 , HES-related repressor protein 1 , HES-related repressor protein 2 , HESR-2 , HRT-2 , cardiovascular basic helix-loop-helix factor 1 , cardiovascular helix-loop-helix factor 1 , class B basic helix-loop-helix protein 32 , hCHF1 , hHRT2 , hairy and enhancer of split-related protein 2 , hairy-related transcription factor 2 , protein gridlock homolog , Hairy-E(spl)-related with YRPW motif 2 , hairy and enhancer of split related 2 , mHRT2 , Herp2 , gridlock , protein gridlock

GENE ID SPECIES
100152404 Sus scrofa
23493 Homo sapiens
15214 Mus musculus
58146 Danio rerio
484115 Canis lupus familiaris
538619 Bos taurus
155430 Rattus norvegicus
421718 Gallus gallus
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