anti-FMR1 (FMR1) 抗体产品概述

Full name:
anti-Fragile X Mental Retardation 1 抗体 (FMR1)
在www.antibodies-online.cn可供173 Fragile X Mental Retardation 1 (FMR1) 抗体的26不同的供货商。 再加上,我们可以发FMR1 蛋白 (7)FMR1 试剂盒 (5)和数多这个蛋白质的别的产品。 总共192 FMR1产品已列进来了。
别名:
AT24755, BcDNA:GM08679, cg6203, dfmr, dfmr1, dFmrp, dfxr, dfxr1, dFXRP, Dmel\\CG6203, dmfr1, EP(3)3517, fmr, Fmr-1, fmr1, Fmrp, FRAXA, FXR, POF, POF1, zFMR1

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引用最多的anti-FMR1 抗体

  1. Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody for ICC, IF - ABIN108599 : Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. in Molecular and cellular biology 2000 (PubMed)
    Show all 7 references for 108599

  2. Bat Polyclonal FMR1 Primary Antibody for WB - ABIN610747 : Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for 610747

  3. Human Polyclonal FMR1 Primary Antibody for ELISA, IHC (p) - ABIN451678 : Hanson, Blank, Valenzuela, Garner, Madison: The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. in The Journal of physiology 2007 (PubMed)

  4. Human Polyclonal FMR1 Primary Antibody for FACS, IHC (p) - ABIN390866 : Yuhas, Walichiewicz, Pan, Zhang, Casillas, Hagerman, Tassone: High-risk fragile x screening in Guatemala: use of a new blood spot polymerase chain reaction technique. in Genetic testing and molecular biomarkers 2009 (PubMed)

  5. Human Polyclonal FMR1 Primary Antibody for ELISA, WB - ABIN4312232 : Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. in Neuron 2007 (PubMed)

  6. Human Polyclonal FMR1 Primary Antibody for ICC, IF - ABIN443330 : Zhang, Brown, Hyland, Chen, Kronengold, Fleming, Kohn, Moroz, Kaczmarek: Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 (PubMed)

更多抗FMR1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Fmr1 protein associates with ninaE (显示 RHO 抗体) mRNA and represses its translation.

  2. Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 (显示 PQBP1 抗体) c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients

  3. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  4. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  5. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (显示 TARDBP 抗体) overexpression

  6. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (显示 LSM14A 抗体) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  7. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  8. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  9. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (显示 H2AFV 抗体).

  10. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Fmr1 knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP, the reader protein Brd4 (显示 BRD4 抗体), appears to be significantly involved in this transcriptional disruption.

  2. The study establishes a functional/physical partnership between FMRP and TDP-43 (显示 TARDBP 抗体) that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.

  3. High CGG trinucleotide repeat expansion in FMR1 gene is associated with fragile X syndrome.

  4. showing the potential of being applicable to other psychiatric disorders to identify endophenotype-specific responses relevant to neurobiology.-Napoli, E., Song, G., Schneider, A., Hagerman, R., Eldeeb, M. A. A. A., Azarang, A., Tassone, F., Giulivi, C. Warburg effect linked to cognitive-executive deficits in FMR1 premutation

  5. Data show that EZH2 (显示 EZH2 抗体) plays a critical role in the FMR1 gene silencing process and that its inhibition can prolong expression of the FMR1 gene even in the presence of its transcript.

  6. Intragenic FMR1 variants, although much less frequent than CGG expansions, are a significant mutational mechanism leading to FXS.

  7. FMR1 triple CGG repeats in the normal range may be associated with primary ovarian insufficiency in China

  8. Expression of FMRpolyG is pathogenic, while the sole expression of CGG RNA is not. FMRpolyG interacts with the nuclear lamina protein LAP2beta (显示 TMPO 抗体) and disorganizes the nuclear lamina architecture in neurons differentiated from FXTAS iPS (显示 SLC27A4 抗体) cells. Finally, expression of LAP2beta (显示 TMPO 抗体) rescues neuronal death induced by FMRpolyG.

  9. FMR1 CGG trinucleotide repeats were low in Caucasian women with diminished ovarian reserve.

  10. For routine screening of patients/carriers with full/pre-mutations of the FMR1 gene in the population.

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (显示 ADAR 抗体) genes and Adar2 (显示 ADARB1 抗体) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Fmr1-KO mice show significantly less daily movement during the dark cycle and more bouts of activity during the light cycle compared with wild types.

  2. these findings support the notion of FMRP differential neuronal regulation and strongly implicate the contribution of fundamental sensory and motor processing at subcortical levels to fragile X syndrome pathology

  3. In Fmr1 KO neurons, Mdm2 (显示 MDM2 抗体) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (显示 MEF2C 抗体) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (显示 TSFM 抗体) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 KO. Expression of a dephosphomimetic of Mdm2 (显示 MDM2 抗体) rescues PSD-95 (显示 DLG4 抗体) ubiquitination, degradation and synapse elimination in Fmr1 KO neurons.

  4. We show here that in mouse models PFC (显示 CFP 抗体) dysfunction in Fragile X Syndrome (FX) can be attributed to the continued absence of FMRP from the PFC (显示 CFP 抗体), independent of FMRP status during development.

  5. Loss of the Fragile X mental retardation protein (显示 NUFIP2 抗体) leads to excessive excitatory compared with inhibitory inputs in neurons extracting information about sound levels. Functionally, this elevated excitation results in increased firing rates, and abnormal coding of frequency and binaural sound localization cues. Imbalanced early-stage sound level processing could partially explain the auditory processing deficits in FXS.

  6. The results of this study suggest dysregulated NMDARs in the pathophysiology of FXS leading to altered mGluR (显示 GRM8 抗体)-mediated Long-Term Depression.

  7. FMRP mediates structural plasticity of olfactory bulb adult-born neurons to support olfactory learning through alphaCaMKII local translation.

  8. This study demonstrated that astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS.

  9. FMRP is involved in pri-miRNA processing via enhancing DROSHA (显示 DROSHA 抗体) expression that may play an important role in fragile X syndrome.

  10. FMRP is likely to participate in retinal physiology, since its expression changes with light exposure. In addition, the expression pattern and regulation by light of FMRP seems well conserved since it was similar in both mouse and chick.

FMR1 抗原简介

Antigen Summary

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Alternative names and synonyms associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1) 抗体
  • fragile X mental retardation 1 (FMR1) 抗体
  • fragile X mental retardation 1 (Fmr1) 抗体
  • fragile X mental retardation 1 (fmr1) 抗体
  • fragile X mental retardation syndrome 1 (Fmr1) 抗体
  • AT24755 抗体
  • BcDNA:GM08679 抗体
  • cg6203 抗体
  • dfmr 抗体
  • dfmr1 抗体
  • dFmrp 抗体
  • dfxr 抗体
  • dfxr1 抗体
  • dFXRP 抗体
  • Dmel\\CG6203 抗体
  • dmfr1 抗体
  • EP(3)3517 抗体
  • fmr 抗体
  • Fmr-1 抗体
  • fmr1 抗体
  • Fmrp 抗体
  • FRAXA 抗体
  • FXR 抗体
  • POF 抗体
  • POF1 抗体
  • zFMR1 抗体

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

GENE ID SPECIES
37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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