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Cdon is required to localize N-cadherin (显示 CDH2 ELISA试剂盒) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (显示 SHH ELISA试剂盒) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (显示 CDO1 ELISA试剂盒) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (显示 MCAM ELISA试剂盒)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (显示 SHH ELISA试剂盒)-receptor components, particularly PTCH1 (显示 PTCH1 ELISA试剂盒), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (显示 SHH ELISA试剂盒) proteins interact with cell adhesion molecule (显示 MCAM ELISA试剂盒), down-regulated by oncogenes (CDO (显示 CDO1 ELISA试剂盒)) and brother of CDO (BOC (显示 BOC ELISA试剂盒)) in a conserved manner
CDO (显示 CDO1 ELISA试剂盒) and BOC (显示 BOC ELISA试剂盒) play a role in differentiation of cells in the skeletal muscle lineage
CDO (显示 CDO1 ELISA试剂盒) and BOC (显示 BOC ELISA试剂盒) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (显示 SHH ELISA试剂盒) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (显示 SHH ELISA试剂盒) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (显示 EPRS ELISA试剂盒) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (显示 MCAM ELISA试剂盒) Cdo (显示 CDO1 ELISA试剂盒) signaling is critical for Inward rectifier potassium channel Kir2.1 (显示 KCNJ2 ELISA试剂盒) activities in the induction of myogenic differentiation.
PKN2 (显示 PKN2 ELISA试剂盒) formed complexes with Cdo (显示 CDO1 ELISA试剂盒), APPL1 (显示 APPL1 ELISA试剂盒) and AKT (显示 AKT1 ELISA试剂盒) via its C-terminal region and this interaction appeared to be important for induction of AKT (显示 AKT1 ELISA试剂盒) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (显示 CDO1 ELISA试剂盒) is required for the full Shh (显示 SHH ELISA试剂盒) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (显示 PTCH1 ELISA试剂盒).
Cx43 (显示 GJA1 ELISA试剂盒) physically interacts with Cdo (显示 CDO1 ELISA试剂盒) to form dynamic complexes during myoblast differentiation
Stim1 (显示 STIM1 ELISA试剂盒) protein levels were decreased in Cdo (显示 CDO1 ELISA试剂盒)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (显示 NFATC3 ELISA试剂盒) activation in Cdo (显示 CDO1 ELISA试剂盒)(-/-) myoblasts upon differentiation.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I