anti-SYNGAP1 (SYNGAP1) 抗体产品概述

Full name:
anti-Synaptic Ras GTPase Activating Protein 1 抗体 (SYNGAP1)
在www.antibodies-online.cn可供76 Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) 抗体的13不同的供货商。 再加上,我们可以发SYNGAP1 蛋白 (3)和数多这个蛋白质的别的产品。 总共85 SYNGAP1产品已列进来了。
别名:
Gm1963, MRD5, RASA1, RASA5, SYNGAP, SYNGAP1
列出全部抗体 基因 基因ID UniProt
SYNGAP1 192117  
SYNGAP1 8831 Q96PV0
SYNGAP1 240057 F6SEU4

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引用最多的anti-SYNGAP1 抗体

  1. Mouse (Murine) Polyclonal SYNGAP1 Primary Antibody for ELISA, WB - ABIN4357271 : Rumbaugh, Adams, Kim, Huganir: SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

更多抗SYNGAP1的相互作用对抗体

Human Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) interaction partners

  1. De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability.

  2. This is the first description of a special electroencephalogram phenomenon (normalization with eye opening) in association with SYNGAP1 mutations.

  3. Syngap transgenic mice exhibited alterations in long-term depression and dendritic spine morphology.

  4. Phosphorylation of synaptic GTPase-activating protein (显示 RASA1 抗体) (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII (显示 CAMK2 抗体)) and cyclin-dependent kinase 5 (CDK5 (显示 CDK5 抗体)) alters the ratio of its GAP activity toward Ras and Rap (显示 LRPAP1 抗体) GTPases.

  5. Reduced cognition in mutant Syngap1 transgenic mice is caused by isolated damage to developing forebrain neurons.

  6. De novo CHD2 (显示 CHD2 抗体) and SYNGAP1 mutations are new causes of epileptic encephalopathies, accounting for 1.2% and 1% of cases, respectively.

  7. De novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYNGAP1 result in a loss of its function, causing intellectual disability, autism, and a specific form of epilepsy.

  8. SYNGAP1 is a brain-specific protein (显示 TPPP3 抗体) that interacts with key components of the proteins involved in experience-dependent changes in glutamate (显示 GRIN1 抗体) synapses involved in learning.

  9. We provide evidence that truncating mutations in SYNGAP1 are common in nonsyndromic intellectual disability and can be also associated with autism.

  10. The C2 domain of SynGAP is essential for stimulation of the Rap (显示 LRPAP1 抗体) GTPase (显示 RACGAP1 抗体) reaction.

Mouse (Murine) Synaptic Ras GTPase Activating Protein 1 (SYNGAP1) interaction partners

  1. Study found that Syngap1 mutations associated with developmental brain disorders disrupt a critical period of neuronal growth, maturation, and dynamics of dendritic structures known to influence de novo assembly of developing cortical circuits

  2. Phosphorylation of synaptic GTPase-activating protein (显示 RASA1 抗体) (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII (显示 CAMK2 抗体)) and cyclin-dependent kinase 5 (CDK5 (显示 CDK5 抗体)) alters the ratio of its GAP activity toward Ras and Rap (显示 LRPAP1 抗体) GTPases.

  3. inactivation of a single copy of syngap1 induced widespread early functional maturation of excitatory connections in the mouse neocortex

  4. These data demonstrate that SynGAP protein acts as a critical developmental repressor of neural excitability that promotes the development of life-long cognitive abilities.

  5. This study demonstrated the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR (显示 GRIN1 抗体) and hippocampal integrity.

  6. Overexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and increasing miniature excitatory synaptic currents amplitude/frequency, respectively.

  7. SynGAP is an important regulator of the release of the neuropeptide calcitonin gene-related peptide (显示 CALCA 抗体) from primary sensory neurons and can modulate capsaicin-induced hypernociception.

  8. Data show that deletion of SynGAP is associated with notable behavioral as well as morphological phenotypes indicative of hippocampal dysfunction.

  9. The GAP activity of synGAP and its association with PSD-95 (显示 DLG4 抗体) are important for normal regulation of spine and synapse formation in hippocampal neurons.

  10. SynGAP expression peaked at times of synaptogenesis and developmental plasticity and SynGAP showed a more spatially restricted pattern as illustrated by its restriction to forebrain

SYNGAP1 抗原简介

Antigen Summary

The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5).

Alternative names and synonyms associated with SYNGAP1

  • synaptic Ras GTPase activating protein 1 (SYNGAP1) 抗体
  • synaptic Ras GTPase activating protein 1 (LOC100352163) 抗体
  • synaptic Ras GTPase activating protein 1 (syngap1) 抗体
  • synaptic Ras GTPase activating protein 1 (Syngap1) 抗体
  • synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1) 抗体
  • Gm1963 抗体
  • MRD5 抗体
  • RASA1 抗体
  • RASA5 抗体
  • SYNGAP 抗体
  • SYNGAP1 抗体

Protein level used designations for SYNGAP1

synaptic Ras GTPase activating protein 1 , neuronal RasGAP , p135 SynGAP , ras GTPase-activating protein SynGAP , ras/Rap GTPase-activating protein SynGAP , synaptic Ras GTPase-activating protein 1 , synaptic Ras-GAP 1 , Ras GTPase-activating protein SynGAP , synaptic Ras GTPase activating protein 1 homolog , synaptic Ras GTPase activating protein, 135kDa

GENE ID SPECIES
717858 Macaca mulatta
746276 Pan troglodytes
100147004 Equus caballus
100352163 Oryctolagus cuniculus
100558580 Anolis carolinensis
192117 Rattus norvegicus
8831 Homo sapiens
481742 Canis lupus familiaris
100525524 Sus scrofa
790307 Bos taurus
240057 Mus musculus
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