Core-Binding Factor, beta Subunit (CBFB) ELISA试剂盒产品概述

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Core-Binding Factor, beta Subunit ELISA试剂盒 (CBFB)
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AI893578, CBF-B, cbf-beta, Cbfb, cbfbeta, Nfya, PEA2, pea2-beta, Pebp2, pebp2-beta, PEBP2B, Pebpb2, unp1266
list all ELISA KIts 基因 基因ID UniProt
大鼠 CBFB CBFB 361391  
小鼠 CBFB CBFB 12400 Q08024
 CBFB CBFB 865 Q13951


适于 Core-Binding Factor, beta Subunit 相互作用对的更多 ELISA 试剂盒

Rhesus Monkey Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Vif (显示 BTG1 ELISA试剂盒) proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G (显示 APOBEC3G ELISA试剂盒).

  2. simian immunodeficiency virus (SIV) Vif (显示 BTG1 ELISA试剂盒) binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G (显示 APOBEC3G ELISA试剂盒)

Mouse (Murine) Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. High CBFB expression is associated with leukemia.

  2. Vif (显示 BTG1 ELISA试剂盒) stabilization by CBFbeta is mainly caused by impairing MDM2 (显示 MDM2 ELISA试剂盒)-mediated degradation.

  3. the mechanistic view that the proliferative function of Crlz-1 (显示 UTP3 ELISA试剂盒) is caused by relaying Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was verified

  4. Core binding factor beta deficiency in chondrocytes caused a decrease of protein levels of Runx transcription factors by accelerating polyubiquitination-mediated proteosomal degradation in vitro

  5. Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 (显示 RUNX2 ELISA试剂盒) protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb skeletons

  6. findings indicate that Cbfbeta stabilizes Runx2 (显示 RUNX2 ELISA试剂盒) in osteoblasts by forming a complex and thus facilitates the proper maintenance of bone mass, particularly cortical bone

  7. Runx/Cbfb signaling regulate androgen receptor (显示 AR ELISA试剂盒) pathway, but does not affect the circulating testosterone levels or the enzymatic conversion to DHT.

  8. Cbfb deficiency results in differentiation blocks and stem cell expansion in hematopoiesis.

  9. Cbfbeta functions in upregulating Ihh (显示 IHH ELISA试剂盒) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (显示 PTH1R ELISA试剂盒) expression to enhance chondrocyte differentiation.

  10. results demonstrate that Cbfbeta mediates cartilage and bone development by interacting with Runx1 (显示 RUNX1 ELISA试剂盒) and Runx2 (显示 RUNX2 ELISA试剂盒) to regulate the expressions of Col (显示 HDAC1 ELISA试剂盒) X and Osx (显示 SP7 ELISA试剂盒) for chondrocyte and osteoblast development

Zebrafish Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 (显示 RUNX3 ELISA试剂盒) expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 (显示 RUNX3 ELISA试剂盒) activity.

  2. characterization of cbfbeta gene

  3. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  4. Data demonstrate for the first time an essential role of JunB (显示 JUNB ELISA试剂盒)-CBFbeta signaling for maintaining sarcomere architecture and function.

Human Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. The co-existence of BCR (显示 BCR ELISA试剂盒)-ABL1 (显示 ABL1 ELISA试剂盒) and CBFB rearrangement is associated with poor outcome and a clinical course similar to that of CML (显示 BCR ELISA试剂盒)-BP, and unlike de novo AML (显示 RUNX1 ELISA试剂盒) with CBFB rearrangement, suggesting that high-intensity chemotherapy with TKI should be considered in these patients.

  2. Moreover, using a CBF-beta loss-of-function mutant, the authors demonstrated that the interaction between CBF-beta and Vif (显示 BTG1 ELISA试剂盒) was not sufficient for Vif (显示 BTG1 ELISA试剂盒) assistance; a region including F68 in CBF-beta was also required for the stability and function of Vif (显示 BTG1 ELISA试剂盒).

  3. Vif (显示 BTG1 ELISA试剂盒) stabilization by CBFbeta is mainly caused by impairing MDM2 (显示 MDM2 ELISA试剂盒)-mediated degradation.

  4. Mutational analysis of CBFbeta revealed that F68 and I55 (显示 FBXL14 ELISA试剂盒) residues are important and participate in a tripartite hydrophobic interaction with W5 of Vif (显示 BTG1 ELISA试剂盒) to maintain a stable and functional Vif (显示 BTG1 ELISA试剂盒)-CBFbeta complex.

  5. Thus, an NGF (显示 NGFB ELISA试剂盒)/TrkA (显示 NTRK1 ELISA试剂盒)-MAPK (显示 MAPK1 ELISA试剂盒)-CBFbeta pathway converges with Islet1 (显示 ISL1 ELISA试剂盒)-Runx1 (显示 RUNX1 ELISA试剂盒) signaling to promote Runx1 (显示 RUNX1 ELISA试剂盒)/CBFbeta holocomplex formation and nonpeptidergic nociceptor maturation.

  6. Our findings demonstrate that HSPCs exposed to non-cytotoxic levels of environmental chemicals and chemotherapeutic agents are prone to topoisomerase II (显示 TOP2 ELISA试剂盒)-mediated DNA damage at the leukemia-associated genes MLL (显示 MLL ELISA试剂盒) and CBFB.

  7. These results provide important information on the assembly of the Vif (显示 BTG1 ELISA试剂盒)-CUL5 (显示 CUL5 ELISA试剂盒)-E3 ubiquitin ligase and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif (显示 BTG1 ELISA试剂盒).

  8. CBF-beta promoted steady-state levels of HIV-1 Vif (显示 BTG1 ELISA试剂盒) by inhibiting the degradation of HIV-1 Vif (显示 BTG1 ELISA试剂盒) through the proteasome pathway.

  9. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC (显示 MYH11 ELISA试剂盒) in proliferation and maintenance of the leukemic phenotype.

  10. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

Core-Binding Factor, beta Subunit (CBFB) 抗原简介

Antigen Summary

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16

Alternative names and synonyms associated with Core-Binding Factor, beta Subunit (CBFB)

  • core-binding factor, beta subunit (Cbfb) Elisa Kit
  • core-binding factor, beta subunit (CBFB) Elisa Kit
  • core-binding factor, beta subunit (LOC100230400) Elisa Kit
  • core-binding factor, beta subunit (cbfb) Elisa Kit
  • core binding factor beta subunit (Cbfb) Elisa Kit
  • core-binding factor, beta subunit (LOC100340362) Elisa Kit
  • core-binding factor, beta subunit (LOC100359284) Elisa Kit
  • core binding factor beta (Cbfb) Elisa Kit
  • nuclear transcription factor-Y alpha (Nfya) Elisa Kit
  • nuclear transcription factor-Y beta (Nfyb) Elisa Kit
  • AI893578 Elisa Kit
  • CBF-B Elisa Kit
  • cbf-beta Elisa Kit
  • Cbfb Elisa Kit
  • cbfbeta Elisa Kit
  • Nfya Elisa Kit
  • PEA2 Elisa Kit
  • pea2-beta Elisa Kit
  • Pebp2 Elisa Kit
  • pebp2-beta Elisa Kit
  • PEBP2B Elisa Kit
  • Pebpb2 Elisa Kit
  • unp1266 Elisa Kit

Protein level used designations for CBFB

core binding factor beta , core-binding factor subunit beta , core-binding factor, beta subunit , core binding factor beta subunit , CBF-beta , PEA2-beta , PEBP2-beta , SL3-3 enhancer factor 1 subunit beta , SL3/AKV core-binding factor beta subunit , polyomavirus enhancer-binding protein 2 beta subunit , CCAAT-binding transcription factor subunit B , core-binding factor beta , SL3-3 enhancer factor 1 beta subunit , polyomavirus enhancer binding protein 2, beta subunit , CAAT box DNA-binding protein subunit A , CAAT-box DNA-binding protein subunit A , CBF-B , NF-YA , nuclear transcription factor Y subunit A , nuclear transcription factor Y subunit alpha , CAAT box DNA-binding protein subunit B , CAAT-box DNA-binding protein subunit B , CBF-A , CCAAT binding transcription factor of CBF-B/NFY-B , CCAAT-binding transcription factor subunit A , NF-YB , nuclear transcription factor - Y beta , nuclear transcription factor Y subunit B , nuclear transcription factor Y subunit beta

361391 Rattus norvegicus
695767 Macaca mulatta
100230400 Taeniopygia guttata
100270773 Xenopus (Silurana) tropicalis
100313579 Saccoglossus kowalevskii
100340362 Oryctolagus cuniculus
100359284 Oryctolagus cuniculus
12400 Mus musculus
30744 Danio rerio
446882 Xenopus laevis
395257 Gallus gallus
865 Homo sapiens
479690 Canis lupus familiaris
614678 Bos taurus
29508 Rattus norvegicus
25336 Rattus norvegicus