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TXK 抗体

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
TXK 抗体  (AA 32-83) TXK 抗体  (AA 32-83) TXK 抗体 (AA 32-83) (ABIN7174076)

TXK 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

TXK 抗体  (AA 131-230) TXK 抗体  (AA 131-230) TXK 抗体 (AA 131-230) (ABIN521176)

TXK 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 2D8 unconjugated

TXK 抗体  (C-Term) TXK 抗体  (C-Term) TXK 抗体 (C-Term) (ABIN570663)

Verified TXK 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated

TXK 抗体 by Grade

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TXK 抗体 by 适用

Find TXK 抗体 for a variety of species such as anti-Human TXK, anti-Mouse TXK, anti-Rat TXK. The species listed below are among those available. Click on a link to go to the corresponding products.

TXK 抗体 by 应用范围

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TXK 抗体 by 抗原表位

Find TXK 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

TXK 抗体 by 克隆形成能力

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TXK 抗体 by 克隆

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TXK 抗体 by 标记

Find TXK 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular TXK 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7174076
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (3)
Cat. No. ABIN521176
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (3)
Cat. No. ABIN570663
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7439636
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN392114
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN307128
Quantity 200 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, WB, IHC, IF, ICC
Validations
  • (1)
Cat. No. ABIN6265813
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7271114
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN7303532
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN359999
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7174079
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7174077
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7174078
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN521180
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
Cat. No. ABIN2576211
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our TXK 抗体

Suzuki, Nara, Suzuki: "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease." in: Clinical medicine & research, Vol. 4, Issue 2, pp. 147-51, (2006) (PubMed).

Takeba, Nagafuchi, Takeno, Kashiwakura, Suzuki: "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2365-70, (2002) (PubMed).

Aliases for TXK 抗体

TXK tyrosine kinase (TXK) 抗体
TXK tyrosine kinase (Txk) 抗体
tyrosine-protein kinase TXK (LOC100544958) 抗体
A130089B16Rik 抗体
BTKL 抗体
Btkl 抗体
PSCTK5 抗体
PTK4 抗体
RLK 抗体
Rlk 抗体
TKL 抗体
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