anti-SH2 Domain Containing 1A (SH2D1A) 抗体产品概述

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anti-SH2 Domain Containing 1A 抗体 (SH2D1A)
在www.antibodies-online.cn可供120 SH2 Domain Containing 1A (SH2D1A) 抗体的20不同的供货商。 再加上,我们可以发SH2 Domain Containing 1A 蛋白 (19)SH2 Domain Containing 1A 试剂盒 (1)和数多这个蛋白质的别的产品。 总共149 SH2 Domain Containing 1A产品已列进来了。
别名:
DSHP, EBVS, Gm686, IMD5, LYP, MTCP1, RGD1562408, SAP, SAP/SH2D1A, SH2D1A, XLP, XLPD

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引用最多的anti-SH2 Domain Containing 1A 抗体

  1. Human Polyclonal SH2D1A Primary Antibody for WB - ABIN1881802 : Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009 (PubMed)
    Show all 5 references for 1881802

  2. Human Monoclonal SH2D1A Primary Antibody for ELISA, WB - ABIN561703 : Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. in Immunology and cell biology 2009 (PubMed)
    Show all 5 references for 561703

  3. Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN185426 : Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. in Blood 2004 (PubMed)

  4. Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN251451 : Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). in Tissue antigens 2004 (PubMed)

  5. Human Polyclonal SH2D1A Primary Antibody for IP, WB - ABIN265020 : Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. in Nature 1998 (PubMed)

更多抗SH2 Domain Containing 1A的相互作用对抗体

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. study concludes that systemic lupus erythematosus (SLE) T cells display reduced levels of the adaptor protein SAP (显示 APCS 抗体), probably as a result of continuous T cell activation and degradation by caspase-3 (显示 CASP3 抗体). Restoration of SAP (显示 APCS 抗体) levels in SLE T cells corrects the overexcitable lupus T cell phenotype.

  2. High LAT1 (显示 LAT PLURAL_@3975@) expression correlated with significantly shorter prostate specific antigen (显示 KLK3 PLURAL_@3975@) recurrence-free survival in patients receiving androgen deprivation therapy

  3. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (显示 SLAMF1 抗体))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (显示 ZMYM2 抗体)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  6. Study of SAP (显示 APCS 抗体) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (显示 CD244 抗体) functional assay allows identification of all cases

  7. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (显示 APCS 抗体) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (显示 SLAMF1 抗体) peptide.

  8. Signaling lymphocytic activation molecule (SLAM)/SLAM (显示 SLAMF1 抗体)-associated protein pathway regulates human B-cell tolerance.

  9. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (显示 APCS 抗体) is nonfunctional, not only abolishing the activating function of 2B4 (显示 CD244 抗体), but rendering this receptor inhibitory.

  10. our data reveal how SAP (显示 APCS 抗体) nucleates a previously unknown signaling complex involving NTB-A (显示 SLAMF6 抗体) and LCK (显示 LCK 抗体) to potentiate restimulation-induced cell death of activated human T cells.

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (显示 APCS 抗体)-dependent activating SFR signaling is essential for NKT (显示 CTSL1 抗体) cell selection.

  2. SAP (显示 APCS 抗体) differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP (显示 APCS 抗体). SAP (显示 APCS 抗体)-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.

  3. SAP (显示 APCS 抗体) is an essential molecule for autoimmune antibody production.

  4. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  5. SLAM (显示 SLAMF1 抗体)-SAP (显示 APCS 抗体) signaling promotes differentiation of IL-17 (显示 IL17A 抗体)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  6. these data suggest that SAP (显示 APCS 抗体) is critical for regulating type II NKT (显示 CTSL1 抗体) cell responses.

  7. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  8. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (显示 APCS 抗体)-/- mice and in Rag-/- mice into which B cells derived from SAP (显示 APCS 抗体)-/- mice together with wt CD4 (显示 CD4 抗体)+ T cells had been transferred.

  9. SAP (显示 APCS 抗体) plays an essential role in CIA (显示 NCOA5 抗体) because of Fyn (显示 FYN 抗体)-independent and Fyn (显示 FYN 抗体)-dependent effects on TFH cells and, possibly, other T cell types.

  10. SAP (显示 APCS 抗体) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

SH2 Domain Containing 1A (SH2D1A) 抗原简介

Antigen Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SH2 Domain Containing 1A (SH2D1A)

  • SH2 domain containing 1A (SH2D1A) 抗体
  • SH2 domain containing 1A (Sh2d1a) 抗体
  • SH2 domain protein 1A (Sh2d1a) 抗体
  • SH21A (LOC780420) 抗体
  • DSHP 抗体
  • EBVS 抗体
  • Gm686 抗体
  • IMD5 抗体
  • LYP 抗体
  • MTCP1 抗体
  • RGD1562408 抗体
  • SAP 抗体
  • SAP/SH2D1A 抗体
  • SH2D1A 抗体
  • XLP 抗体
  • XLPD 抗体

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

GENE ID SPECIES
4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
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