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Human Polyclonal SH2D1A Primary Antibody for WB - ABIN1881802
Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009
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Human Monoclonal SH2D1A Primary Antibody for ELISA, WB - ABIN561703
Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. in Immunology and cell biology 2009
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Human Polyclonal SH2D1A Primary Antibody for IP, WB - ABIN4369745
Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. in Nature 1998
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Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN251451
Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). in Tissue antigens 2004
Human Polyclonal SH2D1A Primary Antibody for ELISA, WB - ABIN250561
Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. in Blood 2004
we describe for the first time the clinical manifestations associated with XLP-1 based on the c.278G>A variant in the SH2D1A gene. The patient had a relatively late age of onset and presented mainly with primary HLH associated with EBV infection without a familial history of immunodeficiency.
this study shows reduced intracellular SAP (显示 APCS 抗体) expression in iNKT cells and other lymphocytes in the blood from common variable immunodeficiency
in X-linked lymphoproliferative disease patient (显示 APCS 抗体)s, SAP deficiency reduces CD74 expression, resulting in the perturbation of B cell maintenance from the naive stage
study concludes that systemic lupus erythematosus (SLE) T cells display reduced levels of the adaptor protein SAP (显示 APCS 抗体), probably as a result of continuous T cell activation and degradation by caspase-3 (显示 CASP3 抗体). Restoration of SAP (显示 APCS 抗体) levels in SLE T cells corrects the overexcitable lupus T cell phenotype.
High LAT1 expression correlated with significantly shorter prostate specific antigen recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (显示 SLAMF1 抗体))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (显示 ZMYM2 抗体)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
Study of SAP (显示 APCS 抗体) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (显示 CD244 抗体) functional assay allows identification of all cases
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (显示 APCS 抗体) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (显示 SLAMF1 抗体) peptide.
naive T cells regulate B cell survival in a SAP (显示 APCS 抗体)-dependent manner
SAP (显示 APCS 抗体)-dependent activating SFR signaling is essential for NKT (显示 CTSL1 抗体) cell selection.
SAP (显示 APCS 抗体) differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP (显示 APCS 抗体). SAP (显示 APCS 抗体)-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.
SAP (显示 APCS 抗体) is an essential molecule for autoimmune antibody production.
SLAM (显示 SLAMF1 抗体)-SAP (显示 APCS 抗体) signaling promotes differentiation of IL-17 (显示 IL17A 抗体)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (显示 APCS 抗体) is critical for regulating type II NKT (显示 CTSL1 抗体) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (显示 APCS 抗体)-/- mice and in Rag-/- mice into which B cells derived from SAP (显示 APCS 抗体)-/- mice together with wt CD4 (显示 CD4 抗体)+ T cells had been transferred.
SAP (显示 APCS 抗体) plays an essential role in CIA (显示 NCOA5 抗体) because of Fyn (显示 FYN 抗体)-independent and Fyn (显示 FYN 抗体)-dependent effects on TFH cells and, possibly, other T cell types.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
, Signaling lymphocytic activation molecule-associated protein
, Duncan disease homolog