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Data suggest that killer cell lectin-like receptors NKR (显示 TACR3 ELISA试剂盒)-P1B:Clr-b (Klrb1 (显示 KLRB1 ELISA试剂盒):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (显示 IFNG ELISA试剂盒) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp (显示 PTHLH ELISA试剂盒)(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (显示 CA2 ELISA试剂盒)+)/CaMK II (显示 CAMK2B ELISA试剂盒), and MAPK (显示 MAPK1 ELISA试剂盒) signaling pathways.
Identification of a novel family of genes, named Clr (显示 CALCR ELISA试剂盒), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr (显示 CALCR ELISA试剂盒)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (显示 CALCR ELISA试剂盒) are intertwined in a genetically conserved NKC region.
these data suggest that LLT1-CD161 (显示 KLRB1 ELISA试剂盒) interactions play a novel and important role in B cell maturation (显示 TNFRSF17 ELISA试剂盒) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (显示 MBL2 ELISA试剂盒)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (显示 KLRB1 ELISA试剂盒) have roles in modulating immune responses to pathogens; and interferon-gamma (显示 IFNG ELISA试剂盒) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (显示 KLRB1 ELISA试剂盒) protein (NKRP1A/KLRB1 (显示 KLRB1 ELISA试剂盒)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (显示 SRC ELISA试剂盒)-PTK, p38 (显示 CRK ELISA试剂盒) and ERK (显示 EPHB2 ELISA试剂盒) signalling pathways, but not PKC, PI3K (显示 PIK3CA ELISA试剂盒) or calcineurin pathways, to increase production of IFN-gamma (显示 IFNG ELISA试剂盒) by human natural killer cells.
LLT1 induces Interferon (显示 IFNA ELISA试剂盒) Type II production by natural killer cells.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells [OCIL].
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
osteoclast inhibitory lectin
, c-type lectin-like receptor
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member D
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, C-type lectin domain family 2 member D5