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CD207 (显示 CD207 ELISA试剂盒)(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP (显示 TSLP ELISA试剂盒) and TGF-beta (显示 TGFB1 ELISA试剂盒) are potential drivers of Langerhans-like cells in vivo.
CD1a+ CD11b (显示 ITGAM ELISA试剂盒)+ macrophages and NK T-cells were found to be significantly increased in inflamed colons of ulcerative colitis patients.
The findings suggest that PLA2 (显示 YWHAZ ELISA试剂盒) inhibition or CD1a blockade may have therapeutic potential for psoriasis.
these observations suggest that CD99 (显示 CD99 ELISA试剂盒) is involved in the regulation of CD1a transcription and expression by increasing ATF-2 (显示 ATF2 ELISA试剂盒).
this study shows that CD1a drove the pathogenesis of poison-ivy dermatitis and psoriasis, and that CD1a-mediated skin inflammation was abrogated by CD1a-blocking antibodies, which highlights CD1a as a target for treatment of inflammatory skin diseases
The data show that immunohistochemistry for CD1a and Hsp60 (显示 HSPD1 ELISA试剂盒) can be of help in differential diagnosis between Keratoacantomas and well-differentiated forms of squamous cell carcinomas.
NDN (显示 NDN ELISA试剂盒) and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas
Findings suggest that dermal survivin (显示 BIRC5 ELISA试剂盒)+CD1a+ (CD1a antigen) cell infiltration may be a potential biomarker of systemic sclerosis skin lesions.
plasma-derived lipids drive functional levels of CD1d (显示 CD1D ELISA试剂盒) expression.
Studies indicate that many CD1 antigen-restricted T cells do not require foreign antigens for activation but instead can be activated by self-lipids presented by CD1.
The expression of CD1d (显示 CD1D ELISA试剂盒) showed a significantly negative correlation with CD86 (显示 CD86 ELISA试剂盒) level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.
our data expose a previously unappreciated role for ILCs in CD1d (显示 CD1D ELISA试剂盒)-mediated immunity, which can modulate tissue homeostasis and inflammatory responses.
CD1d (显示 CD1D ELISA试剂盒)-restricted peripheral T cell lymphoma in mice and humans
Adipocyte CD1d (显示 CD1D ELISA试剂盒) plays a key role in the stimulation of adipose invariant natural killer T cells, leading to anti-inflammatory responses in high-fat diet (HFD)-fed mice.
reduced development of atherosclerosis in hyperlipidaemic mice by the NKT (显示 CTSL1 ELISA试剂盒) antagonist, without affecting NKT (显示 CTSL1 ELISA试剂盒) cell or other lymphocyte numbers, suggests that targeting lesion inflammation via CD1d (显示 CD1D ELISA试剂盒)-dependent activation of NKT (显示 CTSL1 ELISA试剂盒) cells
the crystal structure of the first peptide identified to bind CD1d (显示 CD1D ELISA试剂盒), p99 (显示 PPP1R10 ELISA试剂盒), and show that it binds in the antigen-binding groove of CD1d (显示 CD1D ELISA试剂盒) in a manner compatible with its presentation to T cell receptors.
regulatory and protective role of CD1d (显示 CD1D ELISA试剂盒)-dependent natural killer T cells in contact hypersensitivity, at least in part via regulation of IL-10 (显示 IL10 ELISA试剂盒) producing B(regs)
The findings support a model in which low endosomal pH controls stability and lipid raft localization of CD1d (显示 CD1D ELISA试剂盒)-glycolipid complexes to regulate the outcome of iNKT cell mediated responses.
affects iNKT cell activation by mast cells and release of both IFN-gamma (显示 IFNG ELISA试剂盒) and IL-13 (显示 IL13 ELISA试剂盒)
CD1d (显示 CD1D ELISA试剂盒) acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma (显示 PPARG ELISA试剂盒) activation
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
, CD1.2 antigen
, CD1A antigen, a polypeptide
, CD1a molecule
, T-cell surface glycoprotein CD1A2 antigen
, T-cell surface glycoprotein CD1b
, a polypeptide
, T-cell surface glycoprotein CD1a
, T-cell surface antigen T6/Leu-6
, cluster of differentiation 1 A
, cortical thymocyte antigen CD1A
, differentiation antigen CD1-alpha-3
, epidermal dendritic cell marker CD1a
, hTa1 thymocyte antigen
, CD1b molecule
, T-cell surface glycoprotein CD1d1
, antigen-presenting glycoprotein CD1d1