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Human Polyclonal STUB1 Primary Antibody for IP, PLA - ABIN262267
Tsvetkov, Adamovich, Elliott, Shaul: E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients. in The Journal of biological chemistry 2011
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Human Polyclonal STUB1 Primary Antibody for ELISA, WB - ABIN268811
Jiang, Ballinger, Wu, Dai, Cyr, Höhfeld, Patterson: CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. in The Journal of biological chemistry 2001
Through selective degradation of Clp subunits, AtCHIP could positively regulate homeostasis of Clp proteolytic subunits and maximize the production of functional chloroplasts. Similar results were obtained from transgenic tobacco plants.
we propose that CHIP and NBR1 (显示 NBR1 抗体) mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation
Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (显示 Psmd4 抗体) system.
AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]
The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
Consistent with reduced transcription factor EB (TFEB (显示 TFEB 抗体)) activity, accumulation of phosphorylated TFEB (显示 TFEB 抗体) in STUB1-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB (显示 TFEB 抗体).
ACR (显示 ACR 抗体) interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR (显示 ACR 抗体), and CRL4(CRBN (显示 CRBN 抗体)), which is formed by Cul4a (显示 CUL4A 抗体)/b, Ddb1, and Crbn (显示 CRBN 抗体), and interacts with the COOH terminus of the ACR (显示 ACR 抗体) via Crbn (显示 CRBN 抗体).
The chaperone protein Hsp70 (显示 HSP70 抗体) was found to be important for CHIP and NUCB1 (显示 NUCB1 抗体) interaction as well as CHIP-mediated NUCB1 (显示 NUCB1 抗体) down-regulation.
CHIP is a negative regulator of RIPK1 (显示 RIPK1 抗体) and RIPK3 (显示 RIPK3 抗体), thus inhibiting necroptosis.
our study demonstrated that over-expressing miR (显示 MLXIP 抗体)-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI (显示 CLU 抗体)) through enhancing HIF-1alpha (显示 HIF1A 抗体) activity by targeting CHIP, which may hold great therapeutic promise in treating CLI (显示 CLU 抗体)
PABPN1 (显示 PABPN1 抗体) interacts with and is stabilized by heat shock protein 90 (显示 HSP90 抗体).
CHIP targets Osx (显示 SP7 抗体) for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (显示 TNF 抗体).
CHIP/TRAF3 (显示 TRAF3 抗体)/NIK (显示 MAP4K4 抗体) interactions recruit NIK (显示 MAP4K4 抗体) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (显示 MAP4K4 抗体) at low levels
Cbl-b, together with Stub1, ubiquitinate Foxp3 (显示 FOXP3 抗体), and regulate tTreg development.
CHIP regulates the levels of FMR1 (显示 FMR1 抗体) as an E3 ubiquitin ligase (显示 MUL1 抗体) in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1 (显示 FMR1 抗体)-mediated translational repression by regulating the levels of FMR1 (显示 FMR1 抗体).
these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70 (显示 HSP70 抗体)-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents
Study reveals a mechanism that the Warburg effect is regulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during tumor progression.
The E3 ubiquitin ligase (显示 MUL1 抗体) STUB1 is a negative regulator of both RUNX1 (显示 RUNX1 抗体) and RUNX1 (显示 RUNX1 抗体)-RUNX1T1 (显示 RUNX1T1 抗体). Activation of STUB1 could be a promising therapeutic strategy for RUNX1 (显示 RUNX1 抗体)-RUNX1T1 (显示 RUNX1T1 抗体) leukemia.
Data show that carboxyl-terminus of Hsp70-interacting protein (CHIP) promotes polyubiquitination of transglutaminase 2 (TG2 (显示 TGM2 抗体)) and its subsequent proteasomal degradation.
we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP70-interacting protein (CHIP).
C terminus of Hsc70-interacting protein (显示 ST13 抗体) (CHIP) selectively interacted with epidermal growth factor receptor (EGFR (显示 EGFR 抗体)) mutants and simultaneously induced their ubiquitination and proteasomal degradation.
Study reveals an important function of CHIP-mediated proteolysis in insulin (显示 INS 抗体) and IGF1 (显示 IGF1 抗体) signaling; upon proteotoxic stress conditions and during aging, CHIP is recruited toward disposal of misfolded proteins, reducing its capacity to degrade the INSR (显示 INSR 抗体); identify a degradation pathway that controls the level of active DAF-2 (显示 INSR 抗体)/INSR (显示 INSR 抗体) in C. elegans, Drosophila and human cells.
Overexpression of CHIP decreased intracellular protein (显示 CKAP2 抗体) levels of both G2385R mutant and wild-type LRRK2 (显示 LRRK2 抗体), while short interfering RNA CHIP knockdown had the opposite effect
CHIP directly regulates the stability of CD166 protein through the ubiquitin proteasome system.
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008
STIP1 homology and U-box containing protein 1
, STIP1 homology and U box-containing protein 1
, E3 ubiquitin-protein ligase CHIP
, carboxy terminus of Hsp70-interacting protein
, CLL-associated antigen KW-8
, antigen NY-CO-7
, heat shock protein A binding protein 2 (c-terminal)
, serologically defined colon cancer antigen 7
, STIP1 homology and U-Box containing protein 1