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Data suggest that a hetero-multimer complex forms between light-activated rhodopsin (显示 RHO ELISA试剂盒) and light-activated heterotrimeric transducin (T-alpha-1, Gnb1 (显示 GNB1 ELISA试剂盒), Gngt1 (显示 GNGT1 ELISA试剂盒)); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
These results indicated that efficient Gt activation by rhodopsin (显示 RHO ELISA试剂盒), resulting from an optimized active state of rhodopsin (显示 RHO ELISA试剂盒), is one of the causes of the high amplification efficiency of rods.
These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously.
Three candidate tumor-suppressor genes, SEMA3B (显示 SEMA3B ELISA试剂盒), AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma.
These data suggest that a homozygous missense mutation in GNAT1 is associated with autosomal recessive stationary night blindness.
Expression of GNAT1 gene is down-regulated or absent in nasopharyngeal carcinoma tissues.
Data suggest light reduces oxygen consumption rate (OCR) of retina; light does not affect OCR in retinas of Gnat1-/- knockout mice (phototransduction disabled). Light reduces cGMP in retina; light does not alter cGMP in Gnat1-/- plus Gnat2 (显示 GNAT2 ELISA试剂盒)-/- retina.
Biochemical changes, including reduced transducin protein levels and enhanced transducin GTPase (显示 RACGAP1 ELISA试剂盒) activity, explain the shift in light intensity threshold for Galphat1 translocation in Rs1 (显示 RS1 ELISA试剂盒)-knockout mice.
The results from shaker1 and whirler (显示 DFNB31 ELISA试剂盒) mice suggest that defective transducin translocation may be functionally related to light-induced degeneration.
ectopically expressed cTalpha (显示 PCYT1A ELISA试剂盒) 1) forms a heterotrimeric complex with rod Gbeta (显示 SUCLG2 ELISA试剂盒)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (显示 RHO ELISA试剂盒) or S-cone opsin (显示 RHO ELISA试剂盒)
Oligomerization incompetent retinal degeneration slow (显示 PRPH2 ELISA试剂盒) is associated with mislocalization of cone opsins and cone transducin.
Data show that visual responses in TKO (显示 MRPS12 ELISA试剂盒) mice extend beyond the retina to encompass the lateral margins of the lateral geniculate nucleus and components of the visual cortex.
Thus our results showed that IRD1 and IRD2 mice harbor a nonsense mutation in the Gnat1 gene, resulting in the absence or suppressed expression of the Tralpha protein, which is the likely cause of rod dysfunction in both mutants.
alpha-transducin can function in taste receptor cells and transduce some taste cell responses
data suggest that phosducin (显示 PDC ELISA试剂盒) action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit (显示 POLG ELISA试剂盒).
Alpha-transducin played no role in regulating adaptive response to light. Degeneration does not require transducin-mediated signaling.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
guanine nucleotide-binding protein G(t) subunit alpha-1
, rod-type transducin alpha subunit
, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
, guanine nucleotide binding protein, alpha transducing activity polypeptide 1
, guanine nucleotide-binding protein G(t) subunit alpha-1-like
, transducin alpha-1 chain
, guanine nucleotide-binding protein G(T), alpha-1 subunit
, transducin, rod-specific
, guanine nucleotide binding protein (G protein), alpha transducing 1
, guanine nucleotide binding protein, alpha transducing 1
, Galpha t1
, rod transducin alpha subunit
, transducin alpha (rod)
, rod photoreceptor transducin alpha 1 subunit
, transducin alpha subunit GNAT1