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Cullin 1 蛋白

(Cullin 1 (CUL1))
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).
Cullin 1 Protein (CUL1) (AA 1-776) (GST tag) Cullin 1 Protein (CUL1) (AA 1-776) (GST tag) Cullin 1 Protein (CUL1) (AA 1-776) (GST tag) (ABIN1350756)

CUL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Cullin 1 Protein (CUL1) (AA 477-776) (His-IF2DI Tag) Cullin 1 Protein (CUL1) (AA 477-776) (His-IF2DI Tag) Cullin 1 Protein (CUL1) (AA 477-776) (His-IF2DI Tag) (ABIN7122515)

CUL1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA

Cullin 1 Protein (CUL1) (AA 1-776) (His tag) Cullin 1 Protein (CUL1) (AA 1-776) (His tag) Cullin 1 Protein (CUL1) (AA 1-776) (His tag) (ABIN3092025)

Crystallography grade CUL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

Cullin 1 蛋白 by Grade

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Cullin 1 蛋白 by Origin

Find Cullin 1 蛋白 for a variety of species such as anti-Human Cullin 1, anti-Mouse Cullin 1. The species listed below are among those available. Click on a link to go to the corresponding products.

Cullin 1 蛋白 by Source

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Cullin 1 蛋白 by 蛋白类型

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Cullin 1 蛋白 by 应用范围

Find Cullin 1 蛋白 validated for a specific application such as WB, ELISA, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Cullin 1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1350756
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122515
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092025
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137494
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418857
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN667243
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2712629
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our Cullin 1 蛋白

Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).

Aliases for Cullin 1 蛋白

cullin 1 (CUL1) 蛋白
cullin-1 (LOC100282292) 蛋白
cullin 1 (cul1) 蛋白
cullin-1 (ATEG_00491) 蛋白
cullin-1 (EDI_072700) 蛋白
cullin-1 (EDI_264400) 蛋白
Cullin 1 (SJAG_02591) 蛋白
Cullin-1 (BDBG_03785) 蛋白
cullin 1 (Cul1) 蛋白
cullin 1a (cul1a) 蛋白
cullin 1 S homeolog (cul1.S) 蛋白
Cullin-1 (cul-1) 蛋白
cullin 1b (cul1b) 蛋白
ATCUL1 蛋白
AUXIN RESISTANT 6 蛋白
AXR6 蛋白
Cul-1 蛋白
Cul1 蛋白
cul1 蛋白
Cullin-1 蛋白
cullin-1 蛋白
cullin 1 蛋白
LOC100282292 蛋白
T10P11.26 蛋白
T10P11_26 蛋白
wu:fc13a10 蛋白
wu:fi43h07 蛋白
wu:fj43a08 蛋白
zgc:55483 蛋白
zgc:55747 蛋白
zgc:77500 蛋白
zgc:111899 蛋白
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