CDKL5 (CDKL5) ELISA试剂盒产品概述

Full name:
Cyclin-Dependent Kinase-Like 5 ELISA试剂盒 (CDKL5)
在www.antibodies-online.cn可供0 Cyclin-Dependent Kinase-Like 5 (CDKL5) ELISA试剂盒的不同的供货商。 再加上,我们可以发CDKL5 抗体 (77)CDKL5 蛋白 (4)和数多这个蛋白质的别的产品。 总共86 CDKL5产品已列进来了。
别名:
BC038161, EIEE2, ISSX, Stk9
list all ELISA KIts 基因 基因ID UniProt
 CDKL5 CDKL5 6792 O76039
小鼠 CDKL5 CDKL5 382253 Q3UTQ8
大鼠 CDKL5 CDKL5 100362725  

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适于 CDKL5 相互作用对的更多 ELISA 试剂盒

Human Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR (显示 UTS2R ELISA试剂盒)), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR (显示 UTS2R ELISA试剂盒) isoforms

  2. In the asymptomatic mother, the mutated copy of the CDKL5 gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (显示 IQSEC2 ELISA试剂盒) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 (显示 KCNA2 ELISA试剂盒) in a girl with infantile-onset seizures variant of Rett syndrome (RTT)

  3. The results suggested the mutant CDKL5 was responsible for the Rett syndrome disease.

  4. Rett syndrome with early epilepsy and the congenital variant are mainly due to variations in the CDKL5 and FOXG1 (显示 FOXG1 ELISA试剂盒) genes, respectively

  5. Mutations in exon 8 of cyclin-dependent kinase-like 5 gene (显示 GPD1 ELISA试剂盒) were determined to be disease-causing in epileptic encephalopathy.

  6. study presents the genotype of 2 sisters, a CDKL5 mutation c. 283-3_290del, but different phenotype

  7. Data suggest that the increased dosage of cyclin dependent kinase like 5 protein(CDKL5) might have affected interactions of this kinase with its substrates, leading to perturbation of neurodevelopmental and neurobehavioral abnormalities.

  8. It was indicated that CDKL5 controls excitatory synaptic transmission and the conditions associated with CDKL5 deviation in man indicates synaptic abnormalities.

  9. CDKL5 gene mutations accounted for 5.4% of boys with early onset epileptic encephalopathy

  10. CDKL5 gene is not useful in practical molecular diagnosis of atypical Rett syndrome.

Mouse (Murine) Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. The data of this study demonstrate that dendritic spine stabilization is strongly regulated by CDKL5.

  2. Our findings demonstrate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a critical role in learning and memory.

  3. Nuclear HDAC4 (显示 HDAC5 ELISA试剂盒) binds to chromatin as well as to MEF2A (显示 MEF2A ELISA试剂盒) transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 knockout (Cdkl5 -/Y) mouse model, we found that hypophosphorylated HDAC4 (显示 HDAC5 ELISA试剂盒) translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation.

  4. We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR (显示 UTS2R ELISA试剂盒)), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR (显示 UTS2R ELISA试剂盒) isoforms

  5. Taken together, these results strongly suggested that DYRK1A (显示 DYRK1A ELISA试剂盒) bound to CDKL5 and phosphorylated it on Ser (显示 SIGLEC1 ELISA试剂盒)-308, thus interfering with its nuclear localization.

  6. CDKL5 deletion during development more markedly impairs the establishment of a correct GABAergic cerebellar network than that of glutamatergic one, leading to the behavioural symptoms associated with CDKL5 mutation.

  7. these results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1.

  8. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation

  9. Amph1 (显示 AMPH ELISA试剂盒) is the cytoplasmic substrate for CDKL5.

  10. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes.

CDKL5 抗原简介

Antigen Summary

This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

Alternative names and synonyms associated with CDKL5

  • cyclin-dependent kinase-like 5 (CDKL5) Elisa Kit
  • cyclin-dependent kinase-like 5 (cdkl5) Elisa Kit
  • cyclin-dependent kinase-like 5 (LOC100355402) Elisa Kit
  • cyclin-dependent kinase-like 5 (Cdkl5) Elisa Kit
  • BC038161 Elisa Kit
  • EIEE2 Elisa Kit
  • ISSX Elisa Kit
  • Stk9 Elisa Kit

Protein level used designations for CDKL5

cyclin-dependent kinase-like 5 , cyclin-dependent kinase-like 5-like , cyclin dependent kinase 5 transcript , serine/threonine kinase 9 , serine/threonine-protein kinase 9

GENE ID SPECIES
100057902 Equus caballus
428001 Gallus gallus
100145195 Xenopus (Silurana) tropicalis
100355402 Oryctolagus cuniculus
100407783 Callithrix jacchus
100472831 Ailuropoda melanoleuca
100583908 Nomascus leucogenys
6792 Homo sapiens
382253 Mus musculus
491761 Canis lupus familiaris
100623797 Sus scrofa
538337 Bos taurus
100362725 Rattus norvegicus
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