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Kazrin (显示 KAZ ELISA试剂盒) interacts with ARVCF (显示 ARVCF ELISA试剂盒)-catenin, spectrin and p190B RhoGAP (显示 ARHGAP1 ELISA试剂盒), and modulates RhoA (显示 RHOA ELISA试剂盒) activity.
only collagen-IV (显示 COL4 ELISA试剂盒) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (显示 SRC ELISA试剂盒) phosphorylation, p190RhoGAP (显示 GRLF1 ELISA试剂盒)-B (also known as ARHGAP5) relocalisation and MT1-MMP (显示 MMP14 ELISA试剂盒) (also known as MMP14 (显示 MMP14 ELISA试剂盒)) cell surface exposure at podosome sites.
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (显示 CIITA ELISA试剂盒) (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (显示 ADAMTS9 ELISA试剂盒) (rs7631391), DOCK2 (显示 DOCK2 ELISA试剂盒) (rs77594147), SLC28A1 (显示 SLC28A1 ELISA试剂盒) (rs28649017), ARHGAP5 (rs7151991), and CIITA (显示 CIITA ELISA试剂盒) (rs45601437) in the Asian comparison.
This newly identified miR (显示 MLXIP ELISA试剂盒)-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC (显示 NPC1 ELISA试剂盒) and indicates potential novel therapeutic targets for NPC (显示 NPC1 ELISA试剂盒).
Ectopic expression of p190B suppressed the miR (显示 MLXIP ELISA试剂盒)-494-induced EGFR (显示 EGFR ELISA试剂盒) upregulation.
The expression level of miR (显示 MLXIP ELISA试剂盒)-486-5p was inversely correlated with that of ARHGAP5.
RhoA (显示 RHOA ELISA试剂盒) is down-regulated at cell-cell contacts via p190RhoGAP (显示 GRLF1 ELISA试剂盒)-B in response to tensional homeostasis.
Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting.
A cell cycle-regulated reduction in endogenous p190 (显示 CNTNAP1 ELISA试剂盒) levels is linked to completion of cytokinesis and generation of viable cell progeny.
precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
ARHGAP5 (the gene encoding p190-B RhoGAP (显示 ARHGAP1 ELISA试剂盒)) is a probable target for the amplification at 14q12, and p190-B RhoGAP (显示 ARHGAP1 ELISA试剂盒) promotes cells spreading and migration by negatively regulating RhoA (显示 RHOA ELISA试剂盒) activity in Huh-7 hepatocellular carcinoma cells
Loss of p190-B expression is associated with defective hematopoiesis.
Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS (显示 ROS1 ELISA试剂盒) dependent mechanism.
p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
Mice lacking the Rho-inhibitory protein, p190-B RhoGAP (显示 ARHGAP1 ELISA试剂盒), are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB (显示 CREB1 ELISA试剂盒) transcription factor.
Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
IGF signaling through p190-B and IRS (显示 IARS ELISA试剂盒) proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 5
, chimerin (chimaerin) 1-like
, rho GTPase-activating protein 5-like
, growth factor independent 2
, p100 RasGAP-associated p105 protein
, p105 RhoGAP
, rho GTPase-activating protein 5
, rho-type GTPase-activating protein 5