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Human APOE ELISA Kit for Sandwich ELISA - ABIN2683480
Schultz, Lyons, Franz, Grant, Boake, Jacobson, Xian, Schellenberg, Eisen, Kremen: Apolipoprotein E genotype and memory in the sixth decade of life. in Neurology 2008
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Human APOE ELISA Kit for Sandwich ELISA - ABIN417091
Wu, Liu, Lei, Zhang: Comment on: Cerebrospinal fluid apolipoprotein E concentration decreases after seizure. in Seizure : the journal of the British Epilepsy Association 2010
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Mouse (Murine) APOE ELISA Kit for Sandwich ELISA - ABIN415472
Escolà-Gil, Chen, Julve, Quesada, Santos, Metso, Tous, Jauhiainen, Blanco-Vaca: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties. in Biochimica et biophysica acta 2013
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Human APOE ELISA Kit for Sandwich ELISA - ABIN2345037
Lee, Acosta, Stoeck, Long, Hiet, Mueller, Fackler, Kallis, Bartenschlager: Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. in Journal of virology 2014
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Human APOE ELISA Kit for Sandwich ELISA - ABIN2532293
Johnson, Drugan, Miller, Evans: 38 in 1991
Rat (Rattus) APOE ELISA Kit for Sandwich ELISA - ABIN579777
Burgos-Ramos, Sackmann-Sala, Baquedano, Cruz-Topete, Barrios, Argente, Kopchick: Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers. in Metabolism: clinical and experimental 2012
Human APOE ELISA Kit for Sandwich ELISA - ABIN612665
Butt, Bernhardt, Smolenski, Kotsonis, Fröhlich, Sickmann, Meyer, Lohmann, Schmidt: Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. in The Journal of biological chemistry 2000
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Ovariectomy and ApoE deficiency showed interaction potentializing the insulin (显示 INS ELISA试剂盒) resistance, increasing triglycerides levels and altering angiotensin-converting enzyme (ACE (显示 ACE ELISA试剂盒))-2 (显示 ACE2 ELISA试剂盒) and Mas (显示 MAS1 ELISA试剂盒) receptor gene expressions.
AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease by inhibiting TGF-beta (显示 TGFB1 ELISA试剂盒)/Smad2 (显示 SMAD2 ELISA试剂盒)/STAT3 (显示 STAT3 ELISA试剂盒) signaling.
choroid plexus/CSF (显示 CSF2 ELISA试剂盒) provides an additional source of apoE and the glymphatic fluid transporting system delivers it to brain via the periarterial space
Longxuetongluo capsule inhibits atherosclerosis progression in high-fat diet-induced ApoE(-/-) mice by improving endothelial dysfunction via MAPK (显示 MAPK1 ELISA试剂盒)/IKK (显示 CHUK ELISA试剂盒)/IkappaB/NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway.
Major orthopedic surgery in ApoE-/- mice triggers a systemic inflammatory response. Atherosclerotic plaque area is enlarged after surgery mainly due to an increase of the necrotic core.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE((-/-)) mice via Nrf2 (显示 NFE2L2 ELISA试剂盒) pathway.
Zinc supplementation has a therapeutic effect on the advanced atherosclerosis of ApoE gene-deleted mice, which can significantly improve the efficacy of irbesartan.
Decreased Hexim-1 (显示 HEXIM1 ELISA试剂盒) expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (显示 TGFB1 ELISA试剂盒) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (显示 SOCS3 ELISA试剂盒) respectively.
DPP-4 (显示 DPP4 ELISA试剂盒) inhibitor teneligliptin inhibited atherogenesis in ApoE knockout mice, at least partially, through attenuation of the inflammatory phenotype of perivascular adipose tissue.
The cholesterol metabolism pathway gene-based imaging genetics approach may provide new opportunities to understand the mechanisms underlying Alzheimer's disease and suggested that APOE rs429358 is a core genetic variation that is associated with disease-related differences in brain function.
APOE genotype proportions in patients with persistent HCV infection significantly differed from healthy controls. The distribution of APOE4 allele positive genotypes (epsilon2epsilon4, epsilon3epsilon4, epsilon4epsilon4) also significantly differed between chronically HCV-infected patients and healthy controls. The findings suggest that the APOE4 allele may confer a protective effect in the course of HCV infection.
Study showed that peripheral inflammation interacts with APOE4 and Abeta (显示 APP ELISA试剂盒) to induce and accelerate cerebrovascular and cognitive deficits. Thus, cerebrovascular dysfunction is a key mechanistic process linking Alzheimer's disease hits to pathology.
Results provide no evidence of an association of the APOE E4 and gray matter degenerative changes in patients with Parkinson disease, either with or without dementia.
Study investigated the potential role of APOE epsilon4 in the modulation of grey matter activity, white matter integrity, and brain morphology in healthy APOE epsilon4 carriers when compared to non-carriers. Results suggested that APOE epsilon4 gene can modulate gray matter activity and white matter integrity in cognitive and memory related regions, even before any clinical or neuropsychic symtoms or signs of imminent ...
No APOE e4 effect on cognitive abilities or risk of developing Alzheimer disease.
Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline
Data (including data from studies using transgenic mice) suggest that plasma and liver cholesterol homeostasis and hepatic expression of LDL receptor (显示 LDLR ELISA试剂盒) and lipolysis-stimulated lipoprotein receptor are modulated differently and independently by APOE allele (E4 versus E3) and docosahexaenoic acid intake. (APOE = apolipoprotein E)
In this study, we found no significant association between allele and genotype frequencies of APOE; the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 (显示 LOXL1 ELISA试剂盒) are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.
APOE epsilon4 allele is neither a risk factor for rapid eye movement sleep behavior disorder(RBD (显示 CACNA1D ELISA试剂盒)) nor it is associated with conversion from RBD (显示 CACNA1D ELISA试剂盒) to dementia with Lewy bodies or other synucleinopathies.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (显示 APOA1 ELISA试剂盒) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (显示 HSD11B1 ELISA试剂盒) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (显示 APOB ELISA试剂盒), ApoE, MTP (显示 MTTP ELISA试剂盒), and LDLR (显示 LDLR ELISA试剂盒), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (显示 HSD11B1 ELISA试剂盒) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (显示 APOB ELISA试剂盒)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (显示 MTTP ELISA试剂盒)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3