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Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting.
Hepatic OSTalpha (显示 OSTALPHA 蛋白)-OSTbeta expression is induced by hypoxia.
OSTbeta is a target of RARalpha (显示 RARA 蛋白)-mediated (by binding to DR5 (显示 TNFRSF10B 蛋白) response element) gene regulation pathways
Ostbeta is required for both proper trafficking of Ostalpha (显示 OSTALPHA 蛋白) and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha (显示 OSTALPHA 蛋白)-Ostbeta in different tissues.
OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (显示 SULT2A1 蛋白) homeostasis
OSTbeta has roles in biological transport and is widely expressed in human tissues
overexpr (显示 OSTALPHA 蛋白)ession of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (显示 NR1H4 蛋白) and the activation of FXR target genes
OSTalpha (显示 OSTALPHA 蛋白)/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST (显示 DDOST 蛋白) genes by the nuclear bile acid receptor (显示 NR1H4 蛋白)/farnesoid X receptor (显示 xpr1 蛋白) (FXR (显示 NR1H4 蛋白)).
the selective localization of OSTalpha (显示 OSTALPHA 蛋白) and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
Data suggest that transport of bile acid taurocholate is retained when OstB is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA (organic solute transporter alpha subunit (显示 OSTALPHA 蛋白)); shorter fragments of OstB are inactive.
Co-expression of mouse Ostalpha (显示 OSTALPHA 蛋白)-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha (显示 OSTALPHA 蛋白) and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (显示 NR1H4 蛋白)-/-, mice
In conclusion, we identified Ost-alpha (显示 OSTALPHA 蛋白)/Ost-beta as a novel FXR (显示 NR1H4 蛋白) target. Absent Ost-alpha (显示 OSTALPHA 蛋白)/Ost-beta induction in CA-fed FXR (显示 NR1H4 蛋白)(-/-) animals may contribute to increased liver injury in these animals.
The mouse Ostalpha (显示 OSTALPHA 蛋白) and Ostbeta promoters are unusual in that they contain functional FXR (显示 NR1H4 蛋白) and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.
These results indicate that expression of Ostalpha (显示 OSTALPHA 蛋白) and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (显示 NR1H4 蛋白).
LXRalpha (显示 NR1H3 蛋白) transcriptionally regulate mouse organic solute transporter alpha (显示 OSTALPHA 蛋白)/beta via inverted repeat-1 elements shared with farnesoid X receptor (显示 xpr1 蛋白)
Present as heterodimers (with Ost alpha (显示 OSTALPHA 蛋白)) and/or heteromultimers; the interaction between Ostalpha (显示 OSTALPHA 蛋白) and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.
These data indicate that Ostalpha (显示 OSTALPHA 蛋白)-Ostbeta is essential for intestinal bile acid transport in mice.
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter beta
, organic solute transporter subunit beta
, solute carrier family 51 subunit beta
, organic solute transporter beta subunit
, Ost beta