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Human EGR1 ELISA Kit for Sandwich ELISA - ABIN414979
Zhang, Zhu, Ba, Chen, Zhou, Cao, Wang, Ren, Wu: Gekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factor. in The Journal of biological chemistry 2012
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Mouse (Murine) EGR1 ELISA Kit for Sandwich ELISA - ABIN415740
Moya-Pérez, Romo-Vaquero, Tomás-Barberán, Sanz, García-Conesa: Hepatic molecular responses to Bifidobacterium pseudocatenulatum CECT 7765 in a mouse model of diet-induced obesity. in Nutrition, metabolism, and cardiovascular diseases : NMCD 2013
Human EGR1 ELISA Kit for Sandwich ELISA - ABIN856951
Okuyama, Matsuda, Yamashita, Moriguchi-Goto, Sameshima, Iwakiri, Matsuura, Sato, Asada: Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II. in Circulation journal : official journal of the Japanese Circulation Society 2015
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
aberrant Egr1 expression, which can be suppressed by miR (显示 MLXIP ELISA试剂盒)-181a-5p directly, plays a crucial role in the progression of renal Tubulointerstitial fibrosis in diabetic nephropathy.
Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.
The Egr-1 is essential for CSE-induced MUC5AC production in HBE (显示 HBe1 ELISA试剂盒) cells likely through interaction with and modulation of AP-1 (显示 FOSB ELISA试剂盒), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (显示 ARCN1 ELISA试剂盒).
Finally, the authors show that EGFR (显示 EGFR ELISA试剂盒)-ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.
Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (显示 TGFB1 ELISA试剂盒). Egr-1 mediates TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced COL1A1 (显示 COL1A1 ELISA试剂盒) and COL1A2 (显示 COL1A2 ELISA试剂盒) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced collagen production by attenuating Egr-1 expression in BMFs.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (显示 DAB2 ELISA试剂盒)/DAB2) interactive protein (DAB2IP (显示 DAB2IP ELISA试剂盒)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (显示 DAB2IP ELISA试剂盒) overexpression and STAT3 (显示 STAT3 ELISA试剂盒) inactivation. In addition, NF-kappaB (显示 NFKB1 ELISA试剂盒) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
ROS (显示 ROS1 ELISA试剂盒) activation of the MAPK (ERK (显示 MAPK1 ELISA试剂盒)-1 (显示 MAPK3 ELISA试剂盒)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (显示 PGF ELISA试剂盒) production. Antioxidants could partly abolish these effects.
adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.
KLF12 (显示 KLF12 ELISA试剂盒) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (显示 KLF12 ELISA试剂盒) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (显示 KLF12 ELISA试剂盒) likely plays an important role in CRC (显示 CALR ELISA试剂盒) and could serve as a potential prognostic marker and therapeutic target.
Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (显示 FOXO3 ELISA试剂盒)/EGR1/SIRT1 (显示 SIRT1 ELISA试剂盒) signaling, and AKT (显示 AKT1 ELISA试剂盒) and p300 (显示 EP300 ELISA试剂盒) negatively regulate this process via Bim (显示 BCL2L11 ELISA试剂盒) upregulation.
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (显示 MYOG ELISA试剂盒) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (显示 APP ELISA试剂盒)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.
Egr-1 is a novel regulator of drebrin (显示 DBN1 ELISA试剂盒) expression, which is linked to changes in dendritic spine density
In the present study, we have investigated the contribution of element C to Krox20 (显示 EGR2 ELISA试剂盒) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (显示 EGR2 ELISA试剂盒) initial expression in r3.
HAS2 (显示 HAS2 ELISA试剂盒)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (显示 MAPK3 ELISA试剂盒)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (显示 TGFB1 ELISA试剂盒)-stimulated CD44V6/ERK (显示 EPHB2 ELISA试剂盒)/EGR1 signaling.
Egr1 expression is sensitive to mechanical signals in tendon cells.
age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.
data indicate that Egr-1 promotes Abeta (显示 APP ELISA试剂盒) synthesis via transcriptional activation of BACE-1 (显示 BACE ELISA试剂盒) and suggest that Egr-1 plays role in activation of BACE-1 (显示 BACE ELISA试剂盒) and acceleration of Abeta (显示 APP ELISA试剂盒) synthesis in AD brain.
EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.
EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.
egr1 colocalizes with tyrosine hydroxylase (显示 TH ELISA试剂盒) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (显示 GDF7 ELISA试剂盒)/Smad1 (显示 SMAD1 ELISA试剂盒)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (显示 CREB1 ELISA试剂盒)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A