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LATS1 抗体

(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
LATS1 抗体  (AA 1-280) LATS1 抗体  (AA 1-280) LATS1 抗体 (AA 1-280) (ABIN7169059)

LATS1 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

LATS1 抗体  (AA 521-620) LATS1 抗体  (AA 521-620) LATS1 抗体 (AA 521-620) (ABIN522568)

LATS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated

LATS1 抗体  (Internal Region) LATS1 抗体  (Internal Region) LATS1 抗体 (Internal Region) (ABIN6262920)

LATS1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

LATS1 抗体 by 适用

Find LATS1 抗体 for a variety of species such as anti-Human LATS1, anti-Mouse LATS1, anti-Rat LATS1. The species listed below are among those available. Click on a link to go to the corresponding products.

LATS1 抗体 by 应用范围

Find LATS1 抗体 validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

LATS1 抗体 by 抗体来源

Find LATS1 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

LATS1 抗体 by 抗原表位

Find LATS1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

LATS1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal LATS1 抗体. Click on a link to go to the corresponding products.

LATS1 抗体 by 克隆

Find LATS1 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

LATS1 抗体 by 标记

Find LATS1 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular LATS1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IP, IF
Validations
  • (5)
Cat. No. ABIN7169059
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN522568
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6262920
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
  • (1)
Cat. No. ABIN872292
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN391033
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN3031593
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC (p)
Validations
  • (1)
Cat. No. ABIN5582407
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN2566023
Quantity 50 μg
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6741908
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (2)
Cat. No. ABIN2787626
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN359091
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN877417
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN877403
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN877404
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN2803713
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our LATS1 抗体

Moon, Lee, Lee, Lee, Park, Park, Chang, Park, Choi: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." in: Cells, Vol. 8, Issue 12, (2020) (PubMed).

Wigerius, Quinn, Diab, Clattenburg, Kolar, Qi, Krueger, Fawcett: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).

Huang, Nagatomo, Suzuki, Mizuno, Kumagai, Berezov, Zhang, Karlan, Greene, Wang: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." in: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).

Salah, Melino, Aqeilan: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." in: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).

Mao, Mulvaney, Zakaria, Yu, Morgan, Allen, Basson, Francis-West, Irvine: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." in: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).

Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).

Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

Lee, Kim, Yang, Koo, Oh, Lee, Oh, Lee, Kong, Kim, Lim: "A crucial role of WW45 in developing epithelial tissues in the mouse." in: The EMBO journal, Vol. 27, Issue 8, pp. 1231-42, (2008) (PubMed).

Aliases for LATS1 抗体

large tumor suppressor kinase 1 (LATS1) 抗体
large tumor suppressor (Lats1) 抗体
large tumor suppressor kinase 1 (lats1) 抗体
large tumor suppressor kinase 1 (Lats1) 抗体
large tumor suppressor kinase 1 S homeolog (lats1.S) 抗体
AW208599 抗体
Lats 抗体
lats1 抗体
RGD1564085 抗体
si:dkey-181i3.5 抗体
WARTS 抗体
warts 抗体
wts 抗体
wu:fc19a11 抗体
zgc:123219 抗体
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