beta-2 Microglobulin Protein (AA 21-119) (His tag)
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- 抗原 See all beta-2 Microglobulin (B2M) 蛋白
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
- 蛋白类型
- Recombinant
- 产品特性
- AA 21-119
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This beta-2 Microglobulin protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 产品特性
- B2M, 21-119aa, Human, His tag, E.coli
- 纯度
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product B2M 蛋白
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/ml (determined by Bradford assay)
- 缓冲液
- Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl
- 储存条件
- 4 °C
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- 抗原
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
- 别名
- B2M (B2M 产品)
- 别名
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- 背景
- Beta2 microglobulin, also known as B2M, is a component of MHC class I molecules, Involved in the presentation of peptide antigens to the immune system. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Increased production or destruction of these cells causes B2M levels in the blood to increase. This increase is seen in people with cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma. Multiple myeloma is a malignancy (cancer) of a certain kind of white blood cell, called a plasma cell. B2M Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease. Recombinant B2M protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Beta-2-microglobulin, CDABP0092, HDCMA22P. NCBI no.: NP_004039
- 分子量
- 14.0kDa (120aa), confirmed by MALDI-TOF
- 途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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