WNT3A
(Wingless-Type MMTV Integration Site Family, Member 3A (WNT3A))
蛋白类型
Recombinant
生物活性
Active
产品特性
AA 19-352
宿主
小鼠
资源
Mammalian Cells
应用范围
Functional Studies (Func)
特异性
Stem cell or organoid culture
纯化方法
This protein was purified using a combination of ion exchange, affinity column with Wnt signaling inhibitor-bound sepharose beads, and followed by gel filtration.
纯度
90-95 %
内毒素水平
Less than 0.1 ng/μg (1 IEU/μg)
Biological Activity Comment
Wnt3a activity has been measured using TCF-based Wnt reporter stable cell line. 10 ng/mL of Wnt3a (Lot: 02DEC2015) generate 50- fold increase of luciferase activity compared to control (buffer without Wnt3a). EC50 is about 6 ng/mL.
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背景
Protein Wnt3a is a protein that is encoded by the WNT3A gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis, etc. and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Mouse Wnt3a shows 96 % amino acid identity to human Wnt3a protein.
分子量
41 kDa evaluated by SDS-PAGE under reducing conditions