Plasminogen Activator, Urokinase (PLAU) 蛋白

ABIN491612 产品详细信息, 供应商: Log in to see
蛋白名称
  • PLAU
  • u-PA
  • ATF
  • BDPLT5
  • QPD
  • UPA
  • URK
  • uPA
  • UPAM
  • plasminogen activator, urokinase
  • urokinase-type plasminogen activator
  • PLAU
  • CpipJ_CPIJ002131
  • CpipJ_CPIJ006543
  • CpipJ_CPIJ013396
  • CpipJ_CPIJ013623
  • Plau
宿主

39
7
4
2
2
2
2
1
1
资源
Human
15
11
8
5
5
5
2
1
1
1
蛋白类型
Native
应用范围
Activity Assay (AcA)
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产品特性 Prepared from human urine as the two-chain form. For plasminogen activation and receptor binding studies.
纯化方法 Chromatographically purified
纯度 > 95 % by SDS-PAGE
基因ID 5328
UniProt P00749
途径 Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
限制 仅限研究用
状态 Frozen
浓度 2.5 mg/mL
缓冲液 0.05 M Sodium Acetate, 0.1 M NaCl, 1 mM EDTA, pH 5.0
储存条件 -80 °C
有引用在: Larusch, Merkulova, Mahdi, Shariat-Madar, Sitrin, Cines, Schmaier: "Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 3, pp. H305-20, 2013 (PubMed).

Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: "Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor." in: Circulation, Vol. 124, Issue 17, pp. 1848-59, 2011 (PubMed).

Courey, Horowitz, Kim, Koh, Novak, Subbotina, Warnock, Xue, Cunningham, Lin, Goldklang, Simon, Lawrence, Sisson: "The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice." in: Blood, Vol. 118, Issue 8, pp. 2313-21, 2011 (PubMed).

Szabo, Hobson, List, Molinolo, Lin, Bugge et al.: "Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial ..." in: The Journal of biological chemistry, Vol. 283, Issue 43, pp. 29495-504, 2008 (PubMed).

Lund, Jögi, Rønø, Rasch, Lund, Almholt, Gårdsvoll, Behrendt, Rømer, Høyer-Hansen: "Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32506-15, 2008 (PubMed).

Gardell, Krueger, Antrilli, Elokdah, Mayer, Orcutt, Crandall, Vlasuk: "Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action." in: Molecular pharmacology, Vol. 72, Issue 4, pp. 897-906, 2007 (PubMed).