Prorenin 蛋白

ABIN491434 产品详细信息, 供应商: Log in to see
蛋白名称
  • renin
  • REN
宿主

2
2
2
1
资源
HEK
4
蛋白类型
Native
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产品特性 Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2)
纯化方法 Chromatographically purified
纯度 > 95 % by SDS-PAGE
基因ID 5972
UniProt Q99665
限制 仅限研究用
状态 Frozen
浓度 1.0 mg/mL
缓冲液 10 mM Tris, 0.1M NaCl, pH 8.0
储存条件 -80 °C
厂商提供的图像
Western Blotting (WB) image for Prorenin 蛋白 (ABIN491434) Prorenin protein
有引用在: Yisireyili, Saito, Abudureyimu, Adelibieke, Ng, Nishijima, Takeshita, Murohara, Niwa: "Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells." in: PLoS ONE, Vol. 9, Issue 10, pp. e109268, 2014 (PubMed).