Noggin (NOG) (Active) 蛋白

ABIN413676 产品详细信息, 供应商: Log in to see
蛋白名称
  • noggin
  • SYM1
  • SYNS1
  • nog-A
  • nog1
  • noggin-1
  • noggin
  • noggin protein
  • NOG
  • noggin
  • LOC100033935
  • Nog
  • nog
宿主

34
19
5
3
2
2
1
1
资源
大肠杆菌(E. Coli)
36
5
5
4
4
2
2
1
1
1
蛋白类型
Recombinant
生物活性
Active
应用范围
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
选项
Supplier
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纯度 ≥95 % by SDS-PAGE
≥95 % by HPLC
过滤 Sterile filtered
内毒素水平 <0.1 ng/μg
ProductDetails: Biological Activity Comment Determined by its ability to inhibit 5 ng/ml of BMP-4-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED₅₀ for the effect is 0.05-0.08 μg/ml of Noggin
背景 Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 23.1 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues.

Alternative Names: NOG
分子量 23.1 kDa
基因ID 9241
UniProt Q13253
途径 Stem Cell Maintenance, Tube Formation
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Lyophilized
溶解方式 Reconstitute in H₂O to a concentration of 0.1 to 1.0 mg/mL. Note: Due to solubility reasons the protein should be kept at low pH . This solution can then be diluted into other aqueous buffers
缓冲液 Sterile filtered and lyophilized with no additives
注意事项 Centrifuge the vial prior to opening.
储存条件 -20 °C
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for Noggin (NOG) (Active) protein (ABIN413676) Noggin (NOG) (Active) protein
有引用在: Umezu, Yamanouchi, Iida, Miura, Tomooka: "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 10, pp. 4601-6, 2010 (PubMed).

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