Interleukin 10 (IL10) (Active) 蛋白

ABIN413418 产品详细信息, 供应商: Log in to see
蛋白名称
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF
  • Il-10
  • IL10X
  • interleukin 10
  • IL10
  • Il10
宿主

65
35
22
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
资源
大肠杆菌(E. Coli)
95
26
10
3
3
2
2
2
1
1
1
蛋白类型
Recombinant
生物活性
Active
应用范围
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
选项
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纯度 ≥98 % by SDS-PAGE
≥98 % by HPLC
内毒素水平 <0.1 ng/μg
ProductDetails: Biological Activity Comment The ED₅₀ determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.
背景 IL-10 (Interleukin-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.6 kDa protein containing 161 amino acid residues. It shares over 80 % sequence homology with the Epstein-Barr Virus protein BCRFI. The reported biological activities of IL-10 include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hypersensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production.

Alternative Names: B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.
分子量 19.6 kDa
基因ID 3586
UniProt P22301
研究领域 Cytokines, Immunology, Virology, Inflammation, Cancer
途径 Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Lyophilized
溶解方式 Reconstitute in H₂O a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
缓冲液 Lyophilized from PBS
注意事项 Centrifuge the vial prior to opening.
储存条件 -20 °C
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for Interleukin 10 (IL10) (Active) protein (ABIN413418) Interleukin 10 (IL10) (Active) protein
有引用在: Phadnis-Moghe, Crawford, Kaminski: "Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 144, Issue 1, pp. 39-50, 2015 (PubMed).

Del Galdo, Wermuth, Addya, Fortina, Jimenez et al.: "NF?B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of ..." in: Annals of the rheumatic diseases, Vol. 69, Issue 11, pp. 2024-33, 2010 (PubMed).

van der Vliet, Wang, Yue, Koon, Balk, Exley: "Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 11, pp. 7287-93, 2008 (PubMed).