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Ghrelin/obestatin Prepropeptide (GHRL) (Active) 蛋白

ABIN413323 产品详细信息, 供应商: Log in to see
  • 2210006E23Rik
  • Ghr
  • m46
  • Gh1-1
  • GRHL
  • GHR
  • ghrelin
  • ghrelin-like
  • ghrelin/obestatin preprohormone
  • ghrelin/obestatin prepropeptide
  • Ghrl
  • LOC100349547
  • ghrl
  • GHRL

大肠杆菌(E. Coli)
Functional Studies (Func), SDS-PAGE (SDS), Western Blotting (WB)
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原理 Pure human Gherlin for use in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity..
序列 GS(X)FLSPEHQRVQ QRKESKKPPA KLQPR X = serine modified with n-octanoic acid
背景 Ghrelin ('ghre' is the Proto-Indo-European root of the word 'grow') has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid
Alternate Names: Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
分子量 3.374 kDa
基因ID 51738
UniProt Q9UBU3
研究领域 Cardiovascular, Atherosclerosis, Hormones
途径 Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour
应用备注 Optimal working dilution should be determined by the investigator.

Activity Specification: Biological activity of ghrelin has not been established. The peptide can be used in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity.

限制 仅限研究用
状态 Lyophilized
溶解方式 Reconstitute in PBS containing at least 0.1 % BSA to a concentration of 1.0 mg/mL.
缓冲液 Lyophilized peptide
注意事项 Centrifuge the vial prior to opening.
储存条件 -20 °C
储存方法 -20°C
有效期 12 months
有引用在: Iantorno, Chen, Kim, Tesauro, Lauro, Cardillo, Quon: "Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 292, Issue 3, pp. E756-64, 2007 (PubMed).