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Apolipoprotein A-I (APOA1) 蛋白

ABIN413012 产品详细信息, 供应商: Log in to see
蛋白名称
  • APOA1
  • MGC64335
  • MGC89745
  • apoa-i
  • ApoA-I
  • LOC100136573
  • apoa1
  • Alp-1
  • Apoa-1
  • Brp-14
  • Ltw-1
  • Lvtw-1
  • Sep-1
  • Sep-2
  • Sep2
  • apoA-I
  • Apo-AI
  • ApoAI
  • apoa
  • cb49
  • wu:fb33f01
  • zgc:103718
  • apolipoprotein A-I
  • apolipoprotein A-I-like
  • apolipoprotein A-Ia
  • APOA1
  • LOC100386212
  • apoa1
  • apoa-i
  • LOC100136573
  • Apoa1
  • APOAI
  • apoa1a
宿主

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资源
大肠杆菌(E. Coli)
35
24
17
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蛋白类型
Recombinant
应用范围
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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纯度 ≥97 % by SDS-PAGE
过滤 Sterile filtered
内毒素水平 <0.1 ng/μg
背景 ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the "good cholesterol." The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic Vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

Alternative Names: APOA1, MGC117399, Apoa1, Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, apolipoprotein, apolipoproteins, MGC102525, Sep-1, Sep-2, Sep2, Human ApoA-1, ApoA-1, ApoA1, Apo A1, h-ApoA-1, rh-ApoA-1, recombinant human ApoA-1, ApoA1,recombinant ApoA-1, Apo, ApoA1, Apolipoprotein A-I, Apolipoprotein AI, Apolipoprotein
分子量 28.2 kDa
基因ID 335
NCBI登录号 NM_000039
途径 Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Lyophilized
溶解方式 Reconstitute in H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and store at 4 °C for 1 week or -20 °C for future use.
缓冲液 Sterile filtered and lyophilized with no additives
注意事项 Centrifuge the vial prior to opening.
储存条件 -20 °C
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for Apolipoprotein A-I (APOA1) 蛋白 (ABIN413012) Apolipoprotein A-I (APOA1) protein
有引用在: de Haan, Karasinska, Ruddle, Hayden: "Hepatic ABCA1 expression improves β-cell function and glucose tolerance." in: Diabetes, Vol. 63, Issue 12, pp. 4076-82, 2014 (PubMed).

Saeed, Otsuka, Polavarapu, Karmali, Weiss, Davis, Rostad, Pachura, Adams, Elliott, Taylor, Narula, Kolodgie, Virmani, Hong, Finn: "Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 2, pp. 299-307, 2012 (PubMed).

Barlic, Zhu, Murphy: "Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 7928-36, 2009 (PubMed).