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IL-9 Protein (AA 19-144)

IL9 宿主: 小鼠 宿主: Insect Cells Recombinant > 95 % , as determined by Coomassie stained SDS-PAGE. FACS Active
产品编号 ABIN2666533
发货至: 中国
  • 抗原 See all IL-9 (IL9) 蛋白
    IL-9 (IL9) (Interleukin 9 (IL9))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 19-144
    宿主
    • 16
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    小鼠
    资源
    • 14
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    Insect Cells
    应用范围
    Flow Cytometry (FACS)
    纯度
    > 95 % , as determined by Coomassie stained SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平

    Less than 0.1 EU per μg of protein as determine by the LAL method.

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    Discover our top product IL9 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Biological activity: Mouse IL-9 induces proliferation of MO7e cells. The ED50 is 0.04 - 0.16 ng/ml, corresponding to a specific activity of 6.5 - 25.0 x 106 units/mg.

    限制
    仅限研究用
  • 状态
    Liquid
    溶解方式
    For maximum results, quick spin vial prior to opening. Stock solutions can also be prepared at 50 - 100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2 - 1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
    缓冲液
    0.22 μm filtered protein solution is in PBS.
    注意事项
    Avoid repeated freeze/thaw cycles.
    储存条件
    -20 °C
    储存方法
    Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
  • 抗原
    IL-9 (IL9) (Interleukin 9 (IL9))
    别名
    IL-9 (IL9 产品)
    别名
    IL9 Protein, IL-9 Protein, Il-9 Protein, P40 Protein, HP40 Protein, interleukin 9 Protein, IL9 Protein, il9 Protein, Il9 Protein
    背景
    IL-9 was initially identified in mice as a T cell growth factor. Human and murine IL-9 show 56 % amino acid sequence homology. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation, and prevents apoptosis. The IL-9 receptor consists of the cytokine-specific IL-9 receptor α-chain (IL-9Rα) and the common γ-chain that is shared by IL-2, IL-4, IL-7, IL-15 and IL-21. IL-9 is expressed by activated Th9, Th17, Treg, and mast cells and appears to play important roles in the development and function of subsets within the CD4+ T cell lineage. IL-9 also inhibits immune responses by enhancing the suppressive properties of Tregs and by recruiting immune suppressive mast cells to sites of inflammation. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a key factor in the pathogenesis of bronchial hyperresponsiveness. In this sense, it has been described that IL-9 and IL-9R expression are increased in lungs of asthmatic patients. In addition, IL-9 promotes mast cell mediated intestinal permeability and plays a role in the development of food allergies. Also, IL-9 has been associated with atopic dermatitis.
    分子量
    The 125 amino acid recombinant protein has a predicted molecular mass of approximately 14 kDa. The DTT-reduced protein migrate as multiple bands between 17-25 kDa by SDS-PAGE due to different glycosylation. The predicted N-terminal amino acid is Gln.
    途径
    JAK/STAT Signaling
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