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Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Active) 蛋白

ABIN2469222 产品详细信息, 供应商: Log in to see
蛋白名称
  • Xint-1
  • Xwnt1
  • int-1
  • int1
  • wnt-1
  • wnt1-a
  • Int-1
  • Wnt-1
  • sw
  • swaying
  • BMND16
  • INT1
  • OI15
  • Int1
  • WNT-1
  • sb:eu647
  • zgc:194464
  • zgc:194478
  • WNT1
  • wingless-type MMTV integration site family, member 1
  • wingless-related MMTV integration site 1
  • WNT1
  • wnt1
  • Wnt1
  • WNT-1
宿主

8
资源
大肠杆菌(E. Coli)
6
1
蛋白类型
Recombinant
生物活性
Active
Supplier
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序列 ANSSGRWWGI VNVASSTNLL TDSKSLQLVL EPSLQLLSRK QRRLIRQNPG ILHSVSGGLQ SAVRECKWQF RNRRWNCPTA PGPHLFGKIV NRGCRETAFI FAITSAGVTH SVARSCSEGS IESCTCDYRR RGPGGPDWHW GGCSDNIDFG RLFGREFVDS GEKGRDLRFL MNLHNNEAGR TTVFSEMRQE CKCHGMSGSC TVRTCWMRLP TLRAVGDVLR DRFDGASRVL YGNRGSNRAS RAELLRLEPE DPAHKPPSPH DLVYFEKSPN FCTYSGRLGT AGTAGRACNS SSPALDGCEL LCCGRGHRTR TQRVTERCNC TFHWCCHVSC RNCTHTRVLH ECL
产品特性 The ED50 was determined by its ability to enhance BMP - 2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED50 for this effect is 1.5 - 2.5 ng/mL in the presence of 200 ng/mL of human BMP - 2.
纯度 < 98 % by SDS-PAGE gel and HPLC analyses.
内毒素水平 Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
背景 Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.
基因ID 7471
NCBI登录号 NP_005421
OMIM 4885655
UniProt P04628
途径 WNT signaling, Dopaminergic Neurogenesis
限制 仅限研究用
状态 Lyophilized
注意事项 As with any protein, exposing Wnt-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
储存条件 -20 °C
储存方法 The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Wnt-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
有效期 24 months
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