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Gremlin 1 (GREM1) (Active) 蛋白

ABIN2468502 产品详细信息, 供应商: Log in to see
蛋白名称
  • grem1
  • MGC136702
  • zgc:136702
  • GREM1
  • drm
  • pig2
  • dand2
  • ihg-2
  • gremlin
  • Cktsf1b1
  • Drm
  • Grem
  • ld
  • gremlin-1
  • CKTSF1B1
  • DAND2
  • DRM
  • GREMLIN
  • IHG-2
  • cktsf1b1
  • gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • gremlin 1
  • gremlin 1, DAN family BMP antagonist
  • gremlin-1
  • gremlin-1-like
  • grem1a
  • GREM1
  • Grem1
  • grem1
  • LOC100342066
  • LOC100156280
宿主

23
5
3
3
1
1
资源
CHO Cells
13
8
4
4
3
2
1
1
蛋白类型
Recombinant
生物活性
Active
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序列 KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
产品特性 Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 μg/mL.
纯度 < 90 % by SDS-PAGE gel and HPLC analyses.
背景 Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
基因ID 26585
NCBI登录号 NP_001178251
OMIM 300797307
UniProt O60565
途径 Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
限制 仅限研究用
状态 Lyophilized
注意事项 As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
储存条件 -20 °C
储存方法 The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
有效期 24 months
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