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Pertussis Toxin (ARTC) (Active) 蛋白

ABIN2452202 产品详细信息, 供应商: Log in to see
蛋白名称
宿主
Bordetella pertussis
资源
Bordetella pertussis
蛋白类型
Native
生物活性
Active
应用范围
Functional Studies (Func)
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产品特性 This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
背景 Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
应用备注 1. Studies on the signal transduction of the trimeric GTP binding proteins.
2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
限制 仅限研究用
状态 Liquid
浓度 83 µg/mL
缓冲液 10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
储存条件 -80 °C
厂商提供的图像
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) 蛋白 (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) 蛋白 (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 2)
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) 蛋白 (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 3)
有引用在: Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, 1990 (PubMed).