Pertussis Toxin Protein (ARTC)
ARTC
宿主: Bordetella pertussis
宿主: Bordetella pertussis
Native
Func
Active
(1 reference)-
- 抗原 See all Pertussis Toxin (ARTC) products
- Pertussis Toxin (ARTC)
- 蛋白类型
- Native
- 生物活性
- Active
- 宿主
- Bordetella pertussis
- 资源
- Bordetella pertussis
- 应用范围
- Functional Studies (Func)
- 产品特性
- This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
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- 应用备注
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1. Studies on the signal transduction of the trimeric GTP binding proteins.
2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 83 µg/mL
- 缓冲液
- 10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
- 储存条件
- -80 °C
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: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, (1990) (PubMed).
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: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, (1990) (PubMed).
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- 抗原
- Pertussis Toxin (ARTC)
- 别名
- Pertussis Toxin (ARTC 产品)
- 背景
- Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
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