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Dermonecrotizing Toxin (Active) 蛋白

ABIN2452168 产品详细信息, 供应商: Log in to see
蛋白名称
宿主
Bordetella bronchiseptica
资源
Bordetella bronochiseptica
蛋白类型
Native
生物活性
Active
应用范围
Functional Studies (Func)
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产品特性 Activity: DNT at 5 ng/mL induces ballooning morphological change in cultured mouse osteoblastic cell line MC3T3-E1.
纯度 > 95 % purity by SDS-PAGE (CBB staining)
过滤 Sterile filtered
背景 Dermonecrotic toxin (DNT) is a common toxin produced by pathogenic bacteria belonging to the genus Bordetella, such as B. pertussis, B. parapertussis, and B. bronchiseptica. This toxin activates small GTP-binding proteins such as Rho, Rac and Cdc42 through deamidation or polyamination for downstream signaling pathways. DNT was purified from B. bronchiseptica strain S798 by propriety chromatography and differential precipitation method.
UniProt Q7WGE1
应用备注 1) For the studies of the signaling pathways mediated by small GTP-binding proteins.
2) Antigen to be used for detection of infection of Bordetella by immunological method.
限制 仅限研究用
状态 Liquid
浓度 0.53 mg/mL
缓冲液 50 mM sodium phosphate buffer ( pH 7.2), 1 M urea, 0.3 M sodium sulfate
注意事项 Do not freeze!
储存条件 4 °C
厂商提供的图像
SDS-PAGE (SDS) image for Dermonecrotizing Toxin (Active) 蛋白 (ABIN2452168) Dermonecrotizing Toxin (Active) protein
SDS-PAGE (SDS) image for Dermonecrotizing Toxin (Active) 蛋白 (ABIN2452168) Dermonecrotizing Toxin (Active) protein (Image 2)
SDS-PAGE (SDS) image for Dermonecrotizing Toxin (Active) 蛋白 (ABIN2452168) Dermonecrotizing Toxin (Active) protein (Image 3)
有引用在: Masuda, Betancourt, Matsuzawa, Kashimoto, Takao, Shimonishi, Horiguchi: "Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin." in: The EMBO journal, Vol. 19, Issue 4, pp. 521-30, 2000 (PubMed).

Horiguchi, Nakai, Kume: "Simplified procedure for purification of Bordetella bronchiseptica dermonecrotic toxin." in: FEMS microbiology letters, Vol. 54, Issue 1-3, pp. 39-43, 1990 (PubMed).