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EPH Receptor B4 Protein (EPHB4) (AA 16-539) (His tag,Biotin)

EPHB4 宿主: 人 宿主: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE.
产品编号 ABIN2444108
发货至: 中国
  • 抗原 See all EPH Receptor B4 (EPHB4) 蛋白
    EPH Receptor B4 (EPHB4)
    蛋白类型
    Recombinant
    产品特性
    AA 16-539
    宿主
    • 19
    • 5
    资源
    • 9
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    标记
    This EPH Receptor B4 protein is labelled with His tag,Biotin.
    品牌
    MABSol®,UltraLys
    序列
    AA 16-539
    特异性
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
    产品特性
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 57.8 kDa. The protein migrates as 65-70 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
    纯度
    >97 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product EPHB4 蛋白
  • 说明

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • 抗原
    EPH Receptor B4 (EPHB4)
    别名
    EphB4 (EPHB4 产品)
    别名
    HTK Protein, MYK1 Protein, TYRO11 Protein, htk Protein, myk1 Protein, ephB4a Protein, tyro11 Protein, ephb4b Protein, MGC130997 Protein, AI042935 Protein, Htk Protein, MDK2 Protein, Myk1 Protein, Tyro11 Protein, cb646 Protein, ephB4 Protein, rtk5 Protein, EphB-rtk8 Protein, cb417 Protein, rtk8 Protein, EPH receptor B4 Protein, EPH receptor B4 L homeolog Protein, EPH receptor B4 S homeolog Protein, Eph receptor B4 Protein, eph receptor B4a Protein, eph receptor B4b Protein, EPHB4 Protein, ephb4.L Protein, ephb4.S Protein, ephb4 Protein, Ephb4 Protein, ephb4a Protein, ephb4b Protein
    背景
    Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.
    分子量
    57.9 kDa
    NCBI登录号
    NP_004435
    途径
    RTK signaling
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