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Lymphotoxin-alpha (LTA) (AA 35-205) (Active) 蛋白

ABIN2181836 产品详细信息, 供应商: Log in to see
蛋白名称
  • LT
  • LT-[a]
  • LT-alpha
  • LT[a]
  • LTalpha
  • Ltx
  • TNF-beta
  • TNFSF1
  • Tnfb
  • Tnfsf1b
  • hlb382
  • TNFB
  • lymphotoxin A
  • lymphotoxin alpha
  • lymphotoxin alpha (TNF superfamily, member 1)
  • Lta
  • LTA
产品特性
AA 35-205
14
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
宿主
化学剂
37
21
2
2
1
1
1
1
1
1
1
1
资源
HEK-293 Cells
49
6
3
2
1
1
1
1
蛋白类型
Recombinant
生物活性
Active
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品牌 ActiveMax®
产品特性 This protein carries no "tag". The protein has a calculated MW of 18.7 kDa. The protein migrates as 15 kDa and 19 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
纯度 >95 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 0.05-0.5 ng/mL.
背景 TNF-beta is also known as Lymphotoxin-alpha (LT-alpha or LTA), Tumor necrosis factor ligand superfamily member 1 (TNFSF1), which belongs to the tumor necrosis factor family. TNF-beta can form homotrimer with itself or form heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. The homotrimer of TNF-beta is secreted and the heterotrimer is membrane-associated. The homotrimeric form of NF-beta binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.
分子量 18.7 kDa
NCBI登录号 NP_000586
UniProt P01374
研究领域 Cytokines, Inflammation, Immunology
途径 Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
限制 仅限研究用
状态 Lyophilized
溶解方式 For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for Lymphotoxin-alpha (LTA) (AA 35-205) (Active) 蛋白 (ABIN2181836) Human TNF-beta on SDS-PAGE under reducing (R) condition. The gel was stained overnigh...
Binding Studies (Bind) image for Lymphotoxin-alpha (LTA) (AA 35-205) (Active) 蛋白 (ABIN2181836) Immobilized Human TNF-beta (Cat# TNB-H5214) at 5 μg/mL (100 µl/well), can bind Human...
背景 Voigt, Maurer-Fogy, Adolf: "Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation." in: FEBS letters, Vol. 314, Issue 1, pp. 85-8, 1992 (PubMed).

Gray, Aggarwal, Benton, Bringman, Henzel, Jarrett, Leung, Moffat, Ng, Svedersky: "Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity." in: Nature, Vol. 312, Issue 5996, pp. 721-4, 1985 (PubMed).