MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-308) (Active) protein (His tag)

ABIN2181502 产品详细信息, 供应商: Log in to see
蛋白名称
  • Ica
  • mICA
  • FLJ60820
  • PERB11.1
  • MGC111087
  • MIC-A
  • RIKEN cDNA 1300017J02 gene
  • MHC class I polypeptide-related sequence A
  • 1300017J02Rik
  • MICA
产品特性
AA 24-308
2
2
2
1
1
1
1
1
1
1
1
宿主

18
资源
HEK-293 Cells
5
4
2
2
2
1
1
1
蛋白类型
Recombinant
生物活性
Active
标记
This MICA protein is labelled with His tag.
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产品特性 This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >95 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
背景 MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
分子量 33.6 kDa
NCBI登录号 NP_000238
UniProt Q29983
研究领域 Immunology, Innate Immunity, Adaptive Immunity
途径 Activation of Innate immune Response, Transition Metal Ion Homeostasis
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for MHC Class I Polypeptide-Related Sequence A (MICA) (AA 24-308) (Active) protein (His tag) (ABIN2181502) Human MICA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
背景 Steinle, Li, Morris, Groh, Lanier, Strong, Spies: "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family." in: Immunogenetics, Vol. 53, Issue 4, pp. 279-87, 2001 (PubMed).

Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, 1999 (PubMed).

Groh, Steinle, Bauer, Spies: "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells." in: Science (New York, N.Y.), Vol. 279, Issue 5357, pp. 1737-40, 1998 (PubMed).

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