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Lumican (LUM) (AA 19-338) (Active) protein (His tag)

ABIN2181488 产品详细信息, 供应商: Log in to see
蛋白名称
  • MGC64527
  • zgc:86661
  • ldc
  • slrr2d
  • DKFZp468L1116
  • LDC
  • SLRR2D
  • Ldc
  • lumican
  • LUM
  • lum
  • CpipJ_CPIJ010209
  • Lum
产品特性
AA 19-338
6
2
1
1
1
1
宿主

11
3
1
1
1
1
资源
HEK-293 Cells
5
4
2
2
1
1
1
1
1
蛋白类型
Recombinant
生物活性
Active
标记
His tag
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产品特性 This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >95 % as determined by reduced SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
背景 Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.
分子量 37.5 kDa
NCBI登录号 NP_002336
UniProt P51884
研究领域 Signaling, Extracellular Matrix
途径 Glycosaminoglycan Metabolic Process
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for Lumican (LUM) (AA 19-338) (Active) protein (His tag) (ABIN2181488) Human Lumican, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
背景 Onnerfjord, Heathfield, Heinegård: "Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 26-33, 2003 (PubMed).

Grover, Chen, Korenberg, Roughley: "The human lumican gene. Organization, chromosomal location, and expression in articular cartilage." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21942-9, 1995 (PubMed).