NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.

Interleukin 1 alpha (IL1A) (AA 113-271) (Active) 蛋白

ABIN2181296 产品详细信息, 供应商: Log in to see
蛋白名称
  • Il-1
  • Il-1a
  • IL-1 alpha
  • IL-1A
  • IL1
  • IL1-ALPHA
  • IL1F1
  • IL-1alpha
  • L1A
  • interleukin 1 complex
  • interleukin 1 alpha
  • interleukin 1, alpha
  • Il1
  • Il1a
  • IL1A
产品特性
AA 113-271
28
8
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
宿主

67
31
13
8
7
4
3
3
3
2
2
2
1
1
1
1
1
1
资源
HEK-293 Cells
105
16
5
2
1
1
1
1
蛋白类型
Recombinant
生物活性
Active
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

品牌 ActiveMax®
产品特性 This protein carries no "tag". The protein has a calculated MW of 18 kDa. The protein migrates as 19-22 kDa on a SDS-PAGE gel under reducing (R) condition due to Glycosylation.
纯度 >97 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse D10S cells.The ED50 < 1pg/mL, corresponding to a specific activity of >1,000,000,000 Unit/mg. Measured by its binding ability in a functional ELISA.Immobilized Human IL1R2 /CD121b Protein,C-Fc Tag (Cat# IL2-H4256) at 10 μg/mL (100 μL/well),can bind Recombinant Human IL-1a /Interleukin-1a Protein,HEK293 expressed,ActiveMax (Cat# ILA-H4213).The EC50 is typically 0.5-5 μg/mL.

SDS-PAGE: due to Glycosylation.
背景 Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.
分子量 18 kDa
NCBI登录号 NP_000566
UniProt P01583
研究领域 Cytokines, Immunology, Virology, Inflammation, Cancer
途径 NF-kappaB Signaling, Autophagy
限制 仅限研究用
状态 Lyophilized
溶解方式 For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for Interleukin 1 alpha (IL1A) (AA 113-271) (Active) 蛋白 (ABIN2181296) Human IL-1 alpha on SDS-PAGE under reducing (R) condition. The gel was stained overni...
背景 Dinarello: "Induction of interleukin-1 and interleukin-1 receptor antagonist." in: Seminars in oncology, Vol. 24, Issue 3 Suppl 9, pp. S9-81-S9-93, 1997 (PubMed).

Bankers-Fulbright, Kalli, McKean: "Interleukin-1 signal transduction." in: Life sciences, Vol. 59, Issue 2, pp. 61-83, 1996 (PubMed).