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Interferon gamma Protein (IFNG) (AA 24-166)

IFNG 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
产品编号 ABIN2181249
发货至: 中国
  • 抗原 See all Interferon gamma (IFNG) 蛋白
    Interferon gamma (IFNG)
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 24-166
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    资源
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    HEK-293 Cells
    品牌
    ActiveMax®
    序列
    AA 24-166
    产品特性
    This protein carries no "tag". The protein has a calculated MW of 16.8 kDa. The protein migrates as 17 kDa,20 kDa and 24 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
    纯度
    >90 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product IFNG 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Ross, Pompano: "Diffusion of cytokines in live lymph node tissue using microfluidic integrated optical imaging." in: Analytica chimica acta, Vol. 1000, pp. 205-213, (2018) (PubMed).

    Razaghi, Villacrés, Jung, Mashkour, Butler, Owens, Heimann: "Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells." in: Experimental cell research, Vol. 359, Issue 1, pp. 20-29, (2017) (PubMed).

  • 抗原
    Interferon gamma (IFNG)
    别名
    IFN-gamma (IFNG 产品)
    别名
    IFG Protein, IFI Protein, IFN-g Protein, Ifg Protein, IFNG2 Protein, IFN-gamma Protein, IFN-G Protein, IFNG Protein, IFNgamma Protein, TCRalpha Protein, INF-G Protein, ifng Protein, interferon gamma Protein, interferon, gamma 1-2 Protein, IFNG Protein, Ifng Protein, ifng1-2 Protein
    背景
    Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.
    分子量
    16.8 kDa
    途径
    Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
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